Nitroxazepine Explained

Nitroxazepine (brand name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982.[1] It is also indicated for the treatment of nocturnal enuresis.[1] Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.[2] [3] [4]

Notes and References

  1. Book: Progress in Medicinal Chemistry, Volume 22 (v. 22) . Elsevier Science Publishing Company . 1985 . 246 . 0-444-80668-7 .
  2. Book: Progress in Medicinal Chemistry, Volume 23 (v. 23) . Not Avail . 2000 . 136 . 0-444-80802-7 .
  3. Book: Ann Reports Medicinal Chem V11 (v. 11) . Academic Press Inc . Boston . 1976 . 4 . 0-12-040511-3 .
  4. Johnson O, Jones DW, Nagarajan K, Bhadbhade MM, Venkatesan K . X-ray crystal structure analysis of nitroxazepine: 10-(3-dimethylaminopropyl)-2-nitro-10,11-dihydrodibenz [b,f][l,4]oxazepin-11-one . Journal of Chemical Crystallography . 22 . 5 . 579–583 . 1992 . 10.1007/BF01161343 . 96236391 .

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