Nita Ahuja Explained

Nita Ahuja is a surgeon and the Chair of the Department of Surgery at Yale School of Medicine and Surgeon-in-Chief of Surgery at Yale New Haven Hospital.[1] [2] She is the first woman ever to serve as Chair of Surgery in Yale in its >200 year history. Before taking this position she was the first woman ever to be the Chief of Surgical Oncology at Johns Hopkins Hospital, Baltimore, USA.[3] Ahuja researches in the field of epigenetics and is a passionate advocate of clinician scientist.[4] She also served as the director of Sarcoma and peritoneal surface malignancy program. She is a surgeon-scientist and her research has been cited more than 11,000 times in scientific literature.[5]

Early life and education

Born in India, she migrated to the United States with her parents when she was 8 years old.[6] Her journey into the world of science started as a laboratory technician in Dept. of Immunology, National Institutes of Health (NIH), Bethesda. She was awarded with "Outstanding College Students of America" and "Alpha-omega-alpha original research award" for her outstanding research work. She joined the faculty of Johns Hopkins in 2003 after studying medicine at Duke University and surgery at Johns Hopkins.[3]

Career

Ahuja runs a research laboratory focused on understanding the epigenetic dysregulation in gastrointestinal cancers such as colorectal cancers and pancreas cancers and translating the information to develop biomarkers and epigenetic therapeutics.[7] She has led over twenty national and international clinical trials on testing new therapies in gastrointestinal and breast cancers based on concepts identified in her laboratory.[8] Her work initially as a postdoctoral research fellow twenty years ago identified the concept of CpG island methylator phenotype (CIMP) or CpG island hypermethylation in colorectal cancer.[9] This concept of CIMP now is known to have implications for prognosis as well as response to therapy.[10] CIMP has now been shown to exist in multiple other tumor types such as glioblastomas, leukemia, duodenal cancers etc.[11] [12]

Her laboratory has also identified biomarkers for early detection of colorectal and pancreas cancer using non-invasive body fluids such as serum or plasma.[13] These biomarkers have been licensed and are currently being developed into a commercial assay.[14]

Ahuja also led the epigenetic therapy trials in solid tumors as part of the Stand Up To Cancer consortium since 2008 and since then her laboratory has generated preclinical data for the next generation of clinical epigenetic trials conducted nationally and internationally.[15] [16] She has won several awards over the years including the Abell Foundation Award: Johns Hopkins Alliance for Science and Technology Development in 2014.[17]

Writing

She is co-author of a 2016 report for the Society of University Surgeons on barriers facing surgeon-scientists in basic science.[18] She also co-authored Along with Soft Tissue Sarcomas, An Issue of Surgical Clinics (Volume 88-3) (The Clinics: Surgery (Volume 88-3)).[19]

As well as Johns Hopkins guides for patients, including:

Notes and References

  1. News: Nita Ahuja Named Chair of Surgery. 16 November 2017. 5 September 2019.
  2. Web site: Nita Ahuja > Doctor at Yale Medicine. 2020-07-22. Yale Medicine. en.
  3. Web site: Nita Ahuja M.D.. HopkinsMedicine.org. Johns Hopkins School of Medicine. 23 April 2017.
  4. Web site: Nita Ahuja, MD, MBA, FACS . 2022-04-14 . medicine.yale.edu . en.
  5. Web site: Nita Ahuja, MD, MBA, FACS. 2020-07-22. Yale School of Medicine. en.
  6. Web site: A New Direction for Surgery . 2022-05-16 . Yale Medicine . en.
  7. Web site: Ahuja. Nita. Easwaran. Hariharan. Iacobuzio-Donahue. Christine. (PQD3)Molecular Profiles associated with Long-Term Survival in pancreas Cancer. en.
  8. Web site: Nita Ahuja, MD, MBA, FACS . 2022-04-18 . medicine.yale.edu . en.
  9. 10411935. 96. CpG island methylator phenotype in colorectal cancer. 17576. July 1999. Proc. Natl. Acad. Sci. U.S.A.. 8681–6. Toyota, M.. Ahuja, N.. Ohe-Toyota, M.. Herman, J.G.. James G. Herman. Baylin, S.B.. Stephen B. Baylin. Issa, J.P.. 15. 10.1073/pnas.96.15.8681. 1999PNAS...96.8681T. free.
  10. Web site: Ahuja. Nita. Epigenetic markers involved in colorectal cancer recurrence and metastases. en.
  11. Web site: Nita Ahuja, MD, MBA - Google Scholar. 2020-07-22. scholar.google.com.
  12. Web site: Dr. Nita Ahuja, MD – New Haven, CT General Surgery on Doximity. 2020-07-22. Doximity.
  13. Yi, J.M.. Guzzetta, A.A.. Bailey, V.J.. Downing, S.R.. Van Neste, L.. Chiappinelli, K.B.. Keeley, B.P.. Stark, A.. Herrera, A.. Wolfgang, C.. Pappou, E.P.. Iacobuzio-Donahue, C.A.. Goggins, M.G.. Herman, J.G.. Wang, T.H.. Baylin, S.B.. Ahuja, N.. Novel methylation biomarker panel for the early detection of pancreatic cancer.. Clinical Cancer Research. 1 December 2013. 19. 23. 6544–55. 24088737. 4310572. 10.1158/1078-0432.CCR-12-3224.
  14. Web site: Hey Siri Should I Get a Medical Degree - The ASCO Post. 2020-07-22. www.ascopost.com.
  15. 28186961. 10.18632/oncotarget.15108. 8. Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study. Oncotarget. 35326–35338. Azad, N.S.. El-Khoueiry, A.. Yin, J.. Oberg, A.L.. Flynn, P.. Adkins, D.. Sharma, A.. Weisenberger, D.J.. Brown, T.. Medvari, P.. Jones, P.A.. Easwaran, H.. Kamel, I.. Bahary, N.. Kim, G.. Picus, J.. Pitot, H.C.. Erlichman, C.. Donehower, R.. Shen, H.. Laird, P.W.. Piekarz, R.. Baylin, S.. Ahuja, N.. 2017. 21. 5471058.
  16. 27979916. 10.1158/1078-0432.CCR-16-1729. 23. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study. 5457329. Clin Cancer Res. 2691–2701. Connolly, R.M.. Li, H.. Jankowitz, R.C.. Zhang, Z.. Rudek, M.A.. Jeter, S.C.. Slater, S.A.. Powers, P.. Wolff, A.C.. Fetting, J.H.. Brufsky, A.. Piekarz, R.. Ahuja, N.. Laird, P.W.. Shen, H.. Weisenberger, D.J.. Cope, L.. Herman, J.G.. Somlo, G.. Garcia, A.A.. Jones, P.A.. Baylin, S.B.. Davidson, N.E.. Zahnow, C.A.. Stearns, V.. 2017. 11.
  17. Web site: Nita Ahuja, MD, MBA, FACS . 2022-05-16 . medicine.yale.edu . en.
  18. Keswani, S.G.. Moles, C.M.. Morowitz, M.. Zeh, H.. Kuo, J.S.. Levine, M.H.. Cheng, L.S.. Hackam, D.J.. Ahuja, N.. Goldstein, A.M.. Basic Science Committee of the Society of University Surgeons. The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists.. Annals of Surgery. 2016. 27643928. 10.1097/SLA.0000000000002009. 265. 6. 5450912. 1053–1059.
  19. Book: 978-1416058052. Soft Tissue Sarcomas. Hueman. Matthew T.. Ahuja. Nita. 2008.
  20. Book: Ahuja, Nita. Coleman, JoAnn. Johns Hopkins Patients' Guide to Pancreatic Cancer. 2010. Jones & Bartlett Learning. 9781449632762.
  21. Book: 978-0763774585. Johns Hopkins Patients' Guide to Pancreatic Cancer. Ahuja. Nita. Coleman. Joann. 22 December 2010.
  22. Book: Johns Hopkins Patient Guide to Colon and Rectal Cancer. 2020-07-22. www.amazon.com. 7 March 2013. Jones & Bartlett Learning .
  23. Book: Early Diagnosis and Treatment of Cancer Series: Colorectal Cancer: Expert Consult. 2020-07-22. www.amazon.com. 15 July 2010. Saunders .

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