Nishith Gupta Explained

Nishith Gupta
Birth Date:1977 1, df=y
Thesis Title:"P450 Dependent Alkane Monooxygenase from Acinetobacter sp. EB104"
Thesis Year:2003
Doctoral Advisor:Otmar Asperger
Known For:Optogenetics in Infections,
Membrane biogenesis in Apicomplexan parasites
Website: Official Profile

Nishith Gupta (born January 3, 1977) is an Indian-German molecular biologist and parasitologist known for his pioneering work in the field of Host–pathogen interaction and cell signalling.[1] [2] He is currently working as Professor, Senior Fellow of the Wellcome Trust-DBT (India Alliance)[3] and Head of the Department of Biological Sciences at the Hyderabad campus of Birla Institute of Technology and Science, Pilani.[4] [5]

Early life and education

Nishith Gupta was born in Shahjahanpur, Uttar Pradesh, India. He pursued his early education at the Rohilkhand university (BS), Banaras Hindu University (MS) and later obtained his PhD in biochemistry from Leipzig University (Germany) in 2003.[6] Afterward, he was a post-doctoral fellow at the National Jewish Medical Center in Denver, United States. In 2009, he became a research group leader at the Humboldt University and affiliate scientist at the Max Planck Institute for Infection Biology in Berlin.[7] [8] In 2017, he was awarded Doctor habilitatus (DSc) by Humboldt University in the field of biochemistry and molecular parasitology.[9] In 2020, he returned to India, joining BITS Pilani as a Professor in the Department of Biological Sciences at the Hyderabad campus.

Career and research

Nishith Gupta's research focuses on metabolic interactions between intracellular parasites and host cells.[10] [11] [12] His group has published several research articles focusing on carbon metabolism, membrane biogenesis and signaling pathways primarily in a widespread model parasite Toxoplasma gondii, but also in Plasmodium, and Eimeria species.[13] [14] [15]

Gupta's research on membrane biogenesis in apicomplexan parasites, involving the discovery of unique phospholipids, holds potential for advancing the development of vaccines against parasitic diseases.[16] [17] Notably, his work on phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine identified potential therapeutic targets, while phosphatidylthreonine and a novel phosphatidylserine decarboxylase could serve as toxoplasmosis biomarkers.[18]

In collaboration with researchers at the University of Melbourne[19] and National Key Laboratory of Agricultural Microbiology in Wuhan,[20] [21] Gupta's group has revealed Toxoplasma's metabolic adaptability and identified proteins crucial for the parasite's development, suggesting potential drug targets for toxoplasmosis and related infections.[22] [23] In addition, his group uncovered Plasmodium's reliance on host-derived sugars, offering new directions for the development of anti-malarial drugs.[24]

In a pioneering collaboration with Peter Hegemann, Gupta's work in Optogenetic regulation of cyclic nucleotide signaling within Toxoplasma gondii has paved the way for broader applications of light-activated proteins and biosensors in other intracellular pathogens, including parasites, bacteria, and viruses.[25] [26] [27]

Leadership and initiatives

Throughout his career, Gupta has held leadership positions, including the Heisenberg Fellow of German Research Foundation (DFG) at the Humboldt University[28] and Senior Fellow of the Wellcome Trust-DBT (India Alliance). He is currently serving as the editorial board member of Animal Diseases,[29] Microbial Cell,[30] and Communications Biology published by Nature Portfolio.[31]

In 2021, he founded the Intracellular Parasite Education and Research Labs (iPEARL) in the Biological Science division of BITS Pilani and an integrated One Health initiative – Veterinary And Medical Parasite Infection Research Ensemble (VAMPIRE).[32] These initiatives seek to support the development of future scientists and leaders and contribute to the advancement of our knowledge about parasitic infections in clinical and veterinary settings.[33]

Awards and recognition

In 2010 he was awarded ESCMID research grant for his contribution to the field of clinical microbiology and infectious diseases.[34] In 2014, Nishith Gupta received with the Karl Asmund Rudolphi Medal, an award from the German Society for Parasitology.[35] In 2015, he received the young scientist award in Microbiology from the Robert Koch Foundation.[36] [37] In 2020, he received the Outstanding Potential for Excellence in Research & Academics (OPERA) award from BITS Pilani.[38] Banaras Hindu University honoured him with distinguished alumni award in recognition of his achievements in academics and research.[39] In 2023, Indian Council of Medical Research awarded him an International Fellowships for Senior Biomedical Scientist in collaboration with the SickKids Hospital and University of Toronto.[40] [41]

External links

Notes and References

  1. Web site: Gupta . Nishith . August 2013 . Parasite-Host Interactions – Exploiting the Host . ResearchGate.
  2. Web site: Optobiology in infection EU Researcher . 2023-08-07 . en-US.
  3. Web site: India Alliance – Advancing Discovery & Innovation to Improve Health . 2023-08-05 . www.indiaalliance.org.
  4. Web site: Indian Research Information Network System . 2023-08-05 . irins.inflibnet.ac.in . en.
  5. Web site: About the Editors Molecular determinants of intracellular infection . 2023-11-30 . www.nature.com.
  6. Web site: Group Leader . 2023-08-05 . universe.bits-pilani.ac.in.
  7. Web site: PD Nishith Gupta - Research Portal of the HU Berlin - Research Information System of HU Berlin . 2023-11-30 . fis.hu-berlin.de.
  8. Arroyo-Olarte . Ruben D. . Brouwers . Jos F. . Kuchipudi . Arunakar . Helms . J. Bernd . Biswas . Aindrila . Dunay . Ildiko R. . Lucius . Richard . Gupta . Nishith . 2015-11-13 . Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence . PLOS Biology . en . 13 . 11 . e1002288 . 10.1371/journal.pbio.1002288 . 26565995 . 1545-7885. 4643901 . free .
  9. Web site: nowotnch . Dr. Nishith Gupta . 2023-08-05 . Biologie HU Berlin . en.
  10. Web site: Nishith Gupta . 2023-08-05 . scholar.google.com.
  11. Web site: ORCID . 2023-08-11 . orcid.org.
  12. Web site: Nishith Gupta's schedule for The EMBO Meeting . 2023-08-11 . theembomeeting2012.sched.com.
  13. Web site: 2017-03-23 . Nishith Gupta . 2023-08-05 . www.vetmed.fu-berlin.de . en.
  14. Web site: DFG – GEPRIS – Dr. Nishith Gupta . 2023-08-05 . gepris.dfg.de.
  15. Web site: IISER Pune . 2023-08-07 . www3.iiserpune.ac.in.
  16. Ren . Bingjian . Kong . Pengfei . Hedar . Fatima . Brouwers . Jos F. . Gupta . Nishith . 2020-12-10 . Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii . Communications Biology . en . 3 . 1 . 750 . 10.1038/s42003-020-01480-5 . 2399-3642 . 7728818 . 33303967.
  17. Gupta . Nishith . 22 April 2005 . Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth . . 280 . 16 . 16345–16353 . 10.1074/jbc.M501523200 . 15708856 . free.
  18. Gupta . Nishith . Hartmann . Anne . Lucius . Richard . Voelker . Dennis R. . 2012-06-29 . The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase . The Journal of Biological Chemistry . 287 . 27 . 22938–22947 . 10.1074/jbc.M112.373639 . 1083-351X . 3391113 . 22563079 . free.
  19. Web site: Toxoplasma parasite's greedy appetite may be its downfall . 2023-11-29 . ScienceDaily . en.
  20. Web site: Shen Bang-农业微生物资源发掘与利用全国重点实验室 . 2023-11-29 . hzaml.hzau.edu.cn . en.
  21. Web site: 国家自然科学基金委员会中德科学中心2020年度中德合作交流项目批准通知 . 2024-06-15 . www.nsfc.gov.cn.
  22. Blume . Martin . Rodriguez-Contreras . Dayana . Landfear . Scott . Fleige . Tobias . Soldati-Favre . Dominique . Lucius . Richard . Gupta . Nishith . 2009-08-04 . Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis . Proceedings of the National Academy of Sciences . en . 106 . 31 . 12998–13003 . 10.1073/pnas.0903831106 . 0027-8424 . 2722337 . 19617561 . 2009PNAS..10612998B . free .
  23. Nitzsche . Richard . Günay-Esiyok . Özlem . Tischer . Maximilian . Zagoriy . Vyacheslav . Gupta . Nishith . 2017-09-15 . A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii . Journal of Biological Chemistry . 292 . 37 . 15225–15239 . 10.1074/jbc.M117.802702 . 28726641 . 5602384 . 0021-9258 . free .
  24. Blume . Martin . April 2011 . A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs . The FASEB Journal . en . 25 . 4 . 1218–1229 . 10.1096/fj.10-173278 . free . 0892-6638 . 3058700 . 21169382.
  25. Kuchipudi . Arunakar . Arroyo-Olarte . Ruben D. . Hoffmann . Friederike . Brinkmann . Volker . Gupta . Nishith . 2016-05-02 . Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in Toxoplasma gondii . Microbial Cell (Graz, Austria) . 3 . 5 . 215–223 . 10.15698/mic2016.05.500 . 2311-2638 . 5349149 . 28357357.
  26. Arroyo-Olarte . Ruben Dario . Thurow . Laura . Kozjak-Pavlovic . Vera . Gupta . Nishith . 2018-07-12 . Illuminating pathogen–host intimacy through optogenetics . PLOS Pathogens . en . 14 . 7 . e1007046 . 10.1371/journal.ppat.1007046 . 1553-7374 . 6042787 . 30001435 . free.
  27. Gupta . Nishith . 10 May 2013 . Optogenetic Modulation of an Adenylate Cyclase in Toxoplasma gondii Demonstrates a Requirement of the Parasite cAMP for Host-Cell Invasion and Stage Differentiation . . 288 . 19 . 13705–13717 . 10.1074/jbc.M113.465583 . 3650408 . 23525100 . free.
  28. Web site: CV Nishith Gupta – RWTH Aachen University spp2225 – English . 2023-08-05 . www.spp2225.rwth-aachen.de.
  29. Web site: Animal Diseases . 2023-08-11 . BioMed Central . en.
  30. 1970-01-01 . Editorial Board . Microbial Cell . en . 2311-2638.
  31. Web site: Editorial Board Communications Biology . 2023-08-07 . www.nature.com . en.
  32. Web site: Gupta . Nishith . 2022-12-01 . Prof. Nishith Gupta . 2023-11-28 . BITS Pilani . en-US.
  33. Web site: Instagram . 2023-11-28 . www.instagram.com.
  34. Web site: ESCMID: Awardees 2010 . 2023-08-11 . www.escmid.org.
  35. Web site: Preise Deutsche Gesellschaft für Parasitologie . 2023-08-05 . de-DE.
  36. Web site: Parasito . Postdoktorandenpreis für Dr. Nishith Gupta . 2023-08-05 . Biologie HU Berlin . de.
  37. Web site: Post-doctoral awards for young scientists . 2023-08-05 . www.robert-koch-stiftung.de . en-en.
  38. Web site: BITS . Pilani . 13 July 2020 . OPERA Award .
  39. Web site: Banaras Hindu University, [BHU], Varanasi-221005, U.P., India. – Banaras Hindu University, Varanasi, India. ]. 2023-08-11 . bhu.ac.in.
  40. Web site: DHR . ICMR . International Fellowships for Senior Indian Biomedical Scientist . 24 September 2023 . ICMR.
  41. Web site: Birla Institute of Technology and Science, Pilani on LinkedIn: #bits #bitspilani #bitshyderabad #icmr #dbt #biologicalsciences . 2023-09-24 . www.linkedin.com . en.

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