Niravoline Explained

Niravoline is a chemical compound with the formula . It has diuretic and aquaretic effects and has been studied for its potential use for cerebral edema[1] and cirrhosis.[2]

It exerts its pharmacological effect as a kappa opioid receptor agonist.[3]

Notes and References

  1. 9223533 . 1997 . Guéniau . C. . The kappa opioid agonist niravoline decreases brain edema in the mouse middle cerebral artery occlusion model of stroke . The Journal of Pharmacology and Experimental Therapeutics . 282 . 1 . 1–6 . Oberlander . C. .
  2. 10673065 . 2000 . Gadano . A. . Aquaretic effects of niravoline, a kappa-opioid agonist, in patients with cirrhosis . Journal of Hepatology . 32 . 1 . 38–42 . Moreau . R. . Pessione . F. . Trombino . C. . Giuily . N. . Sinnassamy . P. . Valla . D. . Lebrec . D. . 10.1016/S0168-8278(00)80187-7 .
  3. Web site: Niravoline . NCI Thesaurus . .

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