| Niquinohomo | |
| Settlement Type: | Municipality |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | left |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | Masaya |
| Unit Pref: | Imperial |
| Area Total Km2: | 32 |
| Population As Of: | 2020 |
| Population Footnotes: | [1] |
| Population Total: | 16635 |
| Population Density Km2: | auto |
| Population Urban: | 8550 |
| Coordinates: | 11.9°N -92°W |
| Blank Name: | Climate |
| Blank Info: | Aw |
Niquinohomo (pronounced as /es/) is a municipality in the Masaya department of Nicaragua.It is home to the oldest extant church in Nicaragua; Church of Saint Ann (Iglesia de Santa Ana). The city's patron saint, as well as the birthplace of Augusto César Sandino, after whom the Sandinista movement was named.