Niles Pierce Explained
Niles A. Pierce is an American mathematician, bioengineer, and professor at the California Institute of Technology. He is a leading researcher in the fields of molecular programming and dynamic nucleic acid nanotechnology. His research is focused on kinetically controlled DNA and RNA self-assembly. Pierce is working on applications in bioimaging.
Pierce graduated as the Valedictorian [1] of the Princeton University class of 1993 with a BSE in Mechanical & Aerospace Engineering. He then attended Oxford University as a Rhodes Scholar, an achievement repeated nine years later by his sister Lillian Pierce. He completed a DPhil in Applied Mathematics in 1997. He joined the faculty of the California Institute of Technology in 2000.
Works
- Choi . Harry M. T. . Beck . Victor A. . Pierce . Niles A. . Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability . ACS Nano . American Chemical Society (ACS) . 8 . 5 . 8 April 2014 . 1936-0851 . 10.1021/nn405717p . 4284–4294. 24712299 . 4046802 .
- Hochrein . Lisa M. . Schwarzkopf . Maayan . Shahgholi . Mona . Yin . Peng . Pierce . Niles A. . Conditional Dicer Substrate Formation via Shape and Sequence Transduction with Small Conditional RNAs . Journal of the American Chemical Society . American Chemical Society (ACS) . 135 . 46 . 12 November 2013 . 0002-7863 . 10.1021/ja404676x . 17322–17330. 24219616 . 3842090 .
- Zadeh . Joseph N. . Wolfe . Brian R. . Pierce . Niles A. . Nucleic acid sequence design via efficient ensemble defect optimization . Journal of Computational Chemistry . Wiley . 32 . 3 . 17 August 2010 . 0192-8651 . 10.1002/jcc.21633 . 439–452. 20717905 . 1803200 .
- Zadeh . Joseph N. . Steenberg . Conrad D. . Bois . Justin S. . Wolfe . Brian R. . Pierce . Marshall B. . Khan . Asif R. . Dirks . Robert M. . Pierce . Niles A. . NUPACK: Analysis and design of nucleic acid systems . Journal of Computational Chemistry . Wiley . 32 . 1 . 17 November 2010 . 0192-8651 . 10.1002/jcc.21596 . 170–173. 20645303 . 33709556 . free .
- Choi . Harry M T . Chang . Joann Y . Trinh . Le A . Padilla . Jennifer E . Fraser . Scott E . Pierce . Niles A . Programmable in situ amplification for multiplexed imaging of mRNA expression . Nature Biotechnology . Springer Science and Business Media LLC . 28 . 11 . 31 October 2010 . 1087-0156 . 10.1038/nbt.1692 . 1208–1212. 21037591 . 3058322 .
- Yin . Peng . Choi . Harry M. T. . Calvert . Colby R. . Pierce . Niles A. . Programming biomolecular self-assembly pathways . Nature . Springer Science and Business Media LLC . 451 . 7176 . 2008 . 0028-0836 . 10.1038/nature06451 . 318–322. 18202654 . 2008Natur.451..318Y . 4354536 .
- Dirks . Robert M. . Bois . Justin S. . Schaeffer . Joseph M. . Winfree . Erik . Pierce . Niles A. . Thermodynamic Analysis of Interacting Nucleic Acid Strands . SIAM Review . Society for Industrial & Applied Mathematics (SIAM) . 49 . 1 . 2007 . 0036-1445 . 10.1137/060651100 . 65–88. 2007SIAMR..49...65D .
- Dirks . Robert M. . Pierce . Niles A. . Triggered amplification by hybridization chain reaction . Proceedings of the National Academy of Sciences . 101 . 43 . 18 October 2004 . 0027-8424 . 10.1073/pnas.0407024101 . 15275–15278. 15492210 . 524468 . free .
- Shin . Jong-Shik . Pierce . Niles A. . A Synthetic DNA Walker for Molecular Transport . Journal of the American Chemical Society . American Chemical Society (ACS) . 126 . 35 . 17 August 2004 . 0002-7863 . 10.1021/ja047543j . 10834–10835. 15339155 .
Resources
- NUPACK is a growing software suite for the analysis and design of nucleic acid structures, devices, and systems.
- Molecular Technologies develops and supports programmable molecular technologies for reading out and regulating the state of endogenous biological circuitry.
Startup Company
- Molecular Instruments, Inc. designs and synthesizes molecular kits for multiplexed quantitative bioimaging in academic research, drug development, and clinical diagnostics.
External links
Notes and References
- News: COMMENCEMENT; Princeton President Addresses Graduates. The New York Times. 9 June 1993.
