| Official Name: | Nikolskoye 2-ye |
| Native Name: | Никольское 2-е |
| Native Name Lang: | ru |
| Settlement Type: | Selo |
| Pushpin Map: | Russia Voronezh Oblast#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Type1: | Region |
| Subdivision Name1: | Voronezh Oblast |
| Subdivision Type2: | County |
| Subdivision Type3: | District |
| Subdivision Name3: | Vorobyovsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +3:00 |
| Coordinates: | 50.6°N 50°W[1] |
Nikolskoye 2-ye (Russian: links=no|Никольское 2-е) is a rural locality (a selo) in Nikolskoye 1-ye Rural Settlement, Vorobyovsky District, Voronezh Oblast, Russia. The population was 583 as of 2010.[2] There are 13 streets.[3]
Nikolskoye 2-ye is located 21 km southeast of Vorobyovka (the district's administrative centre) by road. Nikolskoye 1-ye is the nearest rural locality.[4]