| Nikoline Nielsen | |
| Full Name: | Nikoline Lindquist Nielsen |
| Nationality: | Danish |
| Birth Date: | 3 October 1987 |
| Birth Place: | Aalborg, Denmark |
| Height: | 180 cm |
| Position: | Left back |
| Youthclubs1: | Ålholm IF |
| Years1: | 2006-2007 |
| Clubs1: | Lyngby HK |
| Years2: | 2007-2011 |
| Clubs2: | Odense Håndbold (under various Club names) |
| Years3: | 2011-2012 |
| Clubs3: | Slagelse FH |
| Years4: | 2012-2013 |
| Clubs4: | Team Esbjerg |
| Years5: | 2017-2018 |
| Clubs5: | Gudme HK |
Nikoline Nielsen (born 3 October 1987) is a Danish former left back handballer, who played for Slagelse FH.
She became a league player, when she changed from the Danish 1st division club Lyngby HK in 2007 to GOG. When they merged with Odense hf to Odense GOG (becoming HC Odense) she continued there. Before Lyngby HK she played for Ålholm IF and Hillerød.
She began on the Danish national team on 16 October 2007, and as of 12 March 2011 she has played nine games and scored 11 goals. After being out in two years because of an injury, she was selected for the national team again in August 2010.