Nicotine patch explained

A nicotine patch is a transdermal patch that releases nicotine into the body through the skin. It is used in nicotine replacement therapy (NRT), a process for smoking cessation. Endorsed and approved by the U.S. Food and Drug Administration (FDA), it is considered one of the safer NRTs available for the treatment of tobacco use disorder.

Nicotine replacement products including gum and transdermal patches are on the World Health Organization's List of Essential Medicines.[1]

Medical uses

Effectiveness

A meta-analysis found that fewer than 20% of people treated with nicotine replacement therapy remain abstinent from smoking at one year.[2]

History

The first study of the pharmacokinetics of a transdermal nicotine patch in humans was published in 1984[3] by Jed Rose, Murray Jarvik, and Daniel Rose, and was followed by publication by Rose et al. (1985) of results of a study of smokers showing that a transdermal nicotine patch reduced craving for cigarettes.[4] Frank Etscorn filed a patent in the United States on January the 23rd 1985 and was issued the patent on July 1, 1986.[5] The University of California filed a competing patent application nearly three years after Etscorn's filing on February 19, 1988, which was granted on May 1, 1990.[6] Subsequently, the U.S. Patent Office declared an interference action and, after a thorough review of conception, reduction to practice and patent filing dates, issued on September 29, 1993, a priority decision in favor of the Rose et al. patent.[7]

Research

Research has shown that NRT in combination with Cognitive Behavioral Therapy (CBT) can improve the rates of smoking cessation in pregnant women. CBT counseling includes motivational interviewing,[8] Transtheoretical Model of Behavior Change,[9] and Social Cognitive Theory.[10]

Nicotine patches are under study to help relieve the symptoms of postoperative pain[11] and to treat early dementia.[12]

Studies are being conducted about the use of transdermal nicotine patches to treat anxiety, depression, and inattentiveness in subjects with ADHD[13] and to treat late-life depression.[14]

Two small studies have shown that transdermal nicotine patches improve some symptoms of ulcerative colitis.[15] However, this is not the case with Crohn's disease, a similar health condition, where smoking and nicotine intake in general worsen the disease's effects.

Application

The patch is typically worn for 16 to 24 hours.[16] Patches can be removed at night prior to bed if vivid dreams are experienced and undesirable.[17]

Side effects

A study published in the medical journal JAMA Internal Medicine in 2015 found that the most common side effects experienced when using a nicotine patch include: cough, headache, nausea, light-headedness, insomnia, disturbing dreams, sweating, watery eyes, shortness of breath, and skin irritation at the application site. The same study found that the following side effects were reported by patch wearers less frequently: diarrhea, dizziness, coldness in limbs, vomiting, and fast or pounding heart beat.[18]

Availability

Nicotine patches are available for purchase over-the-counter from various manufacturers, without a prescription.[19]

Example of Nicotine Patch Regimen (NicoDerm CQ[20])!NicoDerm CQ patch strength!For a person who smokes 10 or fewer cigarettes per day!For a person who smokes more than 10 cigarettes per day
21 mgDo not use this patch strength.Step 1: Apply 1 patch per day for 6 weeks
14 mgStep 1: Apply 1 patch per day for 6 weeksStep 2: Apply 1 patch per day for 2 weeks
7 mgStep 2: Apply 1 patch per day for 2 weeksStep 3: Apply 1 patch per day for 2 weeks
Total Patch Treatment Period: 8 weeksTotal Patch Treatment Period: 10 weeks

See also

Notes and References

  1. Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . free .
  2. Rosen LJ, Galili T, Kott J, Goodman M, Freedman LS. 2018. Diminishing benefit of smoking cessation medications during the first year: a meta-analysis of randomized controlled trials. Addiction. 113. 5. 805–816. 10.1111/add.14134. 5947828. 29377409.
  3. Rose JE, Jarvik ME, Rose KD . Transdermal administration of nicotine . Drug and Alcohol Dependence . 13 . 3 . 209–13 . May 1984 . 6734425 . 10.1016/0376-8716(84)90061-9 .
  4. Rose JE, Herskovic JE, Trilling Y, Jarvik ME . Transdermal nicotine reduces cigarette craving and nicotine preference . Clinical Pharmacology and Therapeutics . 38 . 4 . 450–6 . October 1985 . 4042528 . 10.1038/clpt.1985.203 . 19915646 .
  5. US . 4597961 . Etscorn, FT .
  6. US . 4920989 .
  7. Web site: Adverse Decisions in Interference. 25 November 2013. 21 February 1995. Board of Patent Appeals & Interferences. OLIVIA M. DUVALL.
  8. Miller. William. Rollnick. Stephen . vanc . May 2003. Motivational Interviewing: Preparing People for Change, 2nd ed.. Journal for Healthcare Quality. 25. 3. 46. 10.1097/01445442-200305000-00013. 1062-2551.
  9. Prochaska JO, DiClemente CC . Stages and processes of self-change of smoking: toward an integrative model of change . Journal of Consulting and Clinical Psychology . 51 . 3 . 390–5 . June 1983 . 6863699 . 10.1037/0022-006x.51.3.390 .
  10. Webb. Mark C. . vanc . 1993. Neurobiology of learning, emotion, and affect. John Madden, ed. Raven Press, Ltd., New York City, New York, 1991. 354 pp. $126.00. Depression. 1. 2. 116–117. 10.1002/depr.3050010211. 1062-6417.
  11. Web site: Nicotine Patch Decreases Post Surgical Pain. MediLexicon International Ltd, Bexhill-on-Sea, UK. 25 November 2013. 15 October 2007.
  12. Web site: Nicotine Patches Up Early Memory Loss In Study. . 3 February 2014. 9 January 2013.
  13. Cocores JA . Transdermal nicotine in adult ADHD with depression and anxiety . Primary Care Companion to the Journal of Clinical Psychiatry . 10 . 3 . 253–4 . 2008 . 18615164 . 2446482 . 10.4088/pcc.v10n0312f .
  14. Web site: Nicotine Patch May Help Late-Life Depression. Medscape. 24 March 2018. 21 March 2018.
  15. Book: Cheah . Matthew . Reena . Khanna . vanc . Current Medical Therapies for Ulcerative Colitis. . Pouchitis and Ileal Pouch Disorders . 1–15 . Academic Press . 2019 .
  16. Web site: Nicotine Replacement Therapy for Quitting Tobacco. www.cancer.org. 2019-10-23.
  17. Web site: Nicotine replacement therapy: MedlinePlus Medical Encyclopedia. medlineplus.gov. 2019-10-23.
  18. Schnoll RA, Goelz PM, Veluz-Wilkins A, Blazekovic S, Powers L, Leone FT, Gariti P, Wileyto EP, Hitsman B . 6 . Long-term nicotine replacement therapy: a randomized clinical trial . JAMA Internal Medicine . 175 . 4 . 504–11 . April 2015 . 25705872 . 4410859 . 10.1001/jamainternmed.2014.8313 .
  19. Commissioner Office . 2019-03-22. Want to Quit Smoking? FDA-Approved Products Can Help. FDA.
  20. Web site: Drugs@FDA: FDA Approved Drug Products. www.accessdata.fda.gov. 2019-10-23.

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