Nicolas Le Novère Explained

Nicolas Le Novère
Birth Date:12 March 1969
Known For:BioModels Database, SBGN, SBML, MIRIAM

Nicolas Le Novère is a British and French biologist. His research focuses on modeling signaling pathways and developing tools to share mathematical models.

Education

Le Novère obtained his Baccalauréat at the Prytanée National Militaire. He received a MSc (1993) in Biology and Biochemistry from the École Normale Supérieure, a BSc in Cellular Biology and Physiology (1991), and a PhD in Molecular and Cellular Pharmacology (1998) from the Pierre and Marie Curie University.[1] From 1999 to 2001, he was a Postdoctoral Fellow at the University of Cambridge (UK).

Research

The first part of Le Novère's career, in the laboratory of Jean-Pierre Changeux at the Pasteur Institute, was focused on studying Nicotinic acetylcholine receptors in the brain. He reconstructed their phylogeny,[2] predicted[3] and modeled their structure.[4] He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.[5] [6]

During his post-doctoral fellowship in the group of Dennis Bray at the University of Cambridge, he modeled the molecular networks underlying bacterial chemotaxis.[7] [8] Le Novère then became involved in the development standards to share mathematical models such as SBML,[9] of which he would later become editor.

In 2003, Le Novère built a research group at the European Bioinformatics Institute (EMBL-EBI). The group studied the signaling pathways underlying synaptic plasticity, in particular the allosteric calcium sensors.[10] [11] [12] In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation SBGN,[13] the guidelines MIRIAM[14] and MIASE,[15] the languages SED-ML[16] and PharmML, and ontologies[17] such as the Systems Biology Ontology. He also created BioModels Database[18] and the Identifiers.org[19] URIs.

Le Novère moved his group to the Babraham Institute from 2012 to 2018.

He was associate editor of the journals BMC Systems Biology and npj Systems Biology and Applications until September 2018. He has been section head for the section Systems and Network Biology of the Faculty of 1000 from 2017 to 2018.

Senior member of the International Society for Computational Biology, he served on its board of directors from 2017 to 2018.

Conviction

In September 2018, Le Novère was sentenced for 8 month (suspended for 2 years) when he admitted downloading indecent images of a child and possession of an extreme pornographic image.[20] [21] [22] Subsequently, he was dismissed from the Babraham Institute where he was working.

External links

Notes and References

  1. Web site: Nicolas Le Novere CV. 25 July 2015.
  2. Le Novère N, Changeux JP . 1995. Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. Journal of Molecular Evolution. 40. 2. 155–172. 10.1007/BF00167110. 7699721. 1995JMolE..40..155L. 2040912.
  3. Le Novère N, Corringer PJ, Changeux JP . 1999. Improved secondary structure predictions for a nicotinic receptor subunit. Incorporation of solvent accessibility and experimental data into a 2D representation. Biophysical Journal. 76. 5. 2329–2345. 10.1016/S0006-3495(99)77390-X. 1300207. 10233052.
  4. Le Novère N, Grutter T, Changeux JP . 2002. Models of the extracellular domain of the nicotinic receptors and of agonist and Ca++ binding sites. Proceedings of the National Academy of Sciences USA. 99. 5. 3210–5. 10.1073/pnas.042699699. 122498. 11867716. 2002PNAS...99.3210L. free.
  5. Le Novère N, Zoli M, Changeux JP . 1996. Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain . European Journal of Neuroscience. 8. 11. 2428–2439. 10.1111/j.1460-9568.1996.tb01206.x. 8950106. 23102912.
  6. Le Novère N, Zoli M, Léna C, Ferrari R, Picciotto MR, Merlo-Pich E, Changeux JP . 1999. Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. NeuroReport. 10. 12. 2497–2501. 10.1097/00001756-199908200-00012. 10574359.
  7. Shimizu TS, Le Novère N, Levin MD, Beavil AJ, Sutton BJ, Bray D . 2000. Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nature Cell Biology. 2. 11. 792–796. 10.1038/35041030. 11056533. 10852897.
  8. Duke . T. A. J. . Le Novère . N. . Bray . D. . 10.1006/jmbi.2001.4610 . Conformational spread in a ring of proteins: A stochastic approach to allostery . Journal of Molecular Biology . 308 . 3 . 541–553 . 2001 . 11327786 . 14914075 .
  9. Hucka . M. . Finney . A. . Sauro . H. M. . Bolouri . H. . Doyle . J. C. . Kitano . H.. Arkin . A. P. . Bornstein . B. J. . Bray . D . Cornish-Bowden . A. . Cuellar . A. A. . Dronov . S. . Gilles . E.D. . Ginkel . M . Gor . V. . Goryanin . I.I. . Hedley . W.J. . Hodgman . T. C. . Hofmeyr . J. -H. . Hunter . P. J. . Juty . N. S. . Kasberger . J. L. . Kremling . A.. Kummer . U. . Le Novère . N. . Loew . L. M. . Lucio . D.. Mendes . P. . Minch . E. . Mjolsness . E.D. . Nakayama. Y.. Nelson. M.R.. Nielsen. P. F.. Sakurada. T.. Schaff. J. C. . Shapiro. B.E.. Shimizu. T. S.. Spence. H. D. . Stelling. J. . Takahashi. K.. Tomita. M. . Wagner . J.. Wang. J.. The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models . Bioinformatics . 19 . 4 . 524–531 . 2003 . 12611808. free . 10.1093/bioinformatics/btg015 .
  10. Stefan MI, Edelstein SJ, Le Novère N . 2008. An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proceedings of the National Academy of Sciences. 105. 31. 10768–10773. 10.1073/pnas.0804672105. 2504824. 18669651. 2008PNAS..10510768S. free.
  11. Li L, Stefan MI, Le Novère N . 2012. Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. PLOS ONE. 7. 9. e43810. 10.1371/journal.pone.0043810. 3433481. 22962589. 2012PLoSO...743810L. free.
  12. Lai M, Brun D, Edelstein SJ, Le Novère N . 2015. Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions. PLOS Computational Biology. 11. 1. e1004063. 10.1371/journal.pcbi.1004063. 4303274. 25611683. 1406.2195. 2015PLSCB..11E4063L. free.
  13. Le Novère N, Hucka M, Mi H, Moodie S, Shreiber F, Sorokin A, Demir E, Wegner K, Aladjem M, Wimalaratne S, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman T, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H . 2009. The Systems Biology Graphical Notation. Nature Biotechnology. 27. 8. 735–741. 10.1038/nbt.1558. 19668183. 11693/38162. free.
  14. Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL . 2005. Minimum Information Requested In the Annotation of biochemical Models (MIRIAM). Nature Biotechnology. 23. 12. 1509–1515. 10.1038/nbt1156. 16333295. free. 11858/00-001M-0000-0010-853F-C. free.
  15. Waltemath D, Adams R, Beard DA, Bergmann FT, Bhalla US, Britten R, Chelliah V, Cooling MT, Cooper J, Crampin E, Garny A, Hoops S, Hucka M, Hunter P, Klipp E, Laibe C, Miller A, Moraru I, Nickerson D, Nielsen P, Nikolski M, Sahle S, Sauro HM, Schmidt H, Snoep JL, Tolle D, Wolkenhauer O, Le Novère N . 2011. Minimum Information About a Simulation Experiment (MIASE. PLOS Computational Biology. 7. 4. e1001122. 10.1371/journal.pcbi.1001122. 3084216. 21552546. 2011PLSCB...7E1122W. free.
  16. Waltemath D, Adams R, Bergmann FT, Hucka M, Kolpakov F, Miller AK, Moraru II, Nickerson D, Sahle S, Snoep JL, Le Novère N . 2011. Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language. BMC Systems Biology. 5. 198. 10.1186/1752-0509-5-198. 3292844. 22172142. free.
  17. Courtot M, Juty N, Knüpfer C, Waltemath D, Zhukova A, Dräger A, Dumontier M, Finney A, Golebiewski M, Hastings J, Hoops S, Keating S, Kell DB, Kerrien S, Lawson J, Lister A, Lu J, Machne R, Mendes P, Pocock M, Rodriguez N, Villeger A, Wilkinson DJ, Wimalaratne S, Laibe C, Hucka M, Le Novère N . 2011. Controlled vocabularies and semantics in Systems Biology. Molecular Systems Biology. 7. 543. 10.1038/msb.2011.77. 3261705. 22027554.
  18. Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M . 2006. BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Research. 34. 90001. D689–D691. 10.1093/nar/gkj092. 1347454. 16381960.
  19. Juty N, Le Novère N, Laibe C . 2012. Identifiers.org and MIRIAM Registry: community resources to provide persistent identification. Nucleic Acids Research. 40. Database issue. D580–D586. 10.1093/nar/gkr1097. 3245029. 22140103.
  20. News: Scientist had abuse film of child, eight . BBC News . 4 September 2018.
  21. News: Pilgrim . Tom . Top Cambridge scientist admits downloading child abuse videos . Cambridge News . 4 September 2018.
  22. Web site: Setting things straight . nlenov.wordpress.com . 20 September 2018 . 24 October 2018.