| Birth Date: | 3 September 1976 |
| Birth Place: | Montevideo, Uruguay |
| Weight: | 235lbs |
| Ru Position: | Flanker |
| Ru Amateuryears: | -2002 |
| Ru Amateurclubs: |  Montevideo Cricket Club |
| Ru Clubyears: | 2002-2006 2006-2007 2007-2010 2014 |
| Ru Proclubs: |  L'Aquila MontaubanOyonnaxUA Libourne |
| Ru Clubcaps: | ? 15 53 8 |
| Ru Clubpoints: | ? (0) (25) (0) |
| Ru Nationalyears: | 1998-2010 |
| Ru Nationalcaps: | 47 |
| Ru Nationalpoints: | (45) |
Nicolas Brignoni (born 3 September 1976 in Montevideo)[1] is a former Uruguayan rugby union player, of Swiss origin. He played as a flanker.
Brignoni played in Europe for L'Aquila Rugby, from Italy, from 2002/2003 to 2005/2006, and US Montauban, from France, in 2006/2007. He played for Oyonnax Rugby, another French team, from 2007/08 to 2009/10. He last played for French side UA Libourne in the Fédérale 1, in 2014.
He holds 47 caps with 9 tries scored, 45 points in aggregate, for Uruguay national rugby union team. His first game was at 8 June 1998 in a 72-5 loss to Argentina XV, in Buenos Aires, in a tour. He played four games at the 1999 Rugby World Cup, scoring a try, and three games at the 2003 Rugby World Cup, where he scored an important try against Georgia. He had his last cap at the 21-21 draw with Romania, at 23 November 2010, for the 2011 Rugby World Cup qualification repechage, in Montevideo.