| Birth Date: | 3 September 1976 |
| Birth Place: | Montevideo, Uruguay |
| Weight: | 235lbs |
| Position: | Flanker |
| Amatyears1: | -2002 |
| Amatteam1: | Montevideo Cricket Club |
| Years1: | 2002-2006 |
| Years2: | 2006-2007 |
| Years3: | 2007-2010 |
| Years4: | 2014 |
| Clubs1: | L'Aquila |
| Clubs2: | Montauban |
| Clubs3: | Oyonnax |
| Clubs4: | UA Libourne |
| Apps2: | 15 |
| Apps3: | 53 |
| Apps4: | 8 |
| Points2: | 0 |
| Points3: | 25 |
| Points4: | 0 |
| Repyears1: | 1998-2010 |
| Repcaps1: | 47 |
| Reppoints1: | 45 |
Nicolas Brignoni (born 3 September 1976 in Montevideo)[1] is a former Uruguayan rugby union player, of Swiss origin. He played as a flanker.
Brignoni played in Europe for L'Aquila Rugby, from Italy, from 2002/2003 to 2005/2006, and US Montauban, from France, in 2006/2007. He played for Oyonnax Rugby, another French team, from 2007/08 to 2009/10. He last played for French side UA Libourne in the Fédérale 1, in 2014.
He holds 47 caps with 9 tries scored, 45 points in aggregate, for Uruguay national rugby union team. His first game was at 8 June 1998 in a 72-5 loss to Argentina XV, in Buenos Aires, in a tour. He played four games at the 1999 Rugby World Cup, scoring a try, and three games at the 2003 Rugby World Cup, where he scored an important try against Georgia. He had his last cap at the 21-21 draw with Romania, at 23 November 2010, for the 2011 Rugby World Cup qualification repechage, in Montevideo.