| Nicolae Crețulescu (Nicolae Kretzulescu) | |
| Order: | 2nd Prime Minister of Romania |
| Term Start: | 24 June 1862 - 11 October 1863 14 June 1865 |
| Term End: | 11 February 1866 |
| Predecessor: | Barbu Catargiu Mihail Kogălniceanu |
| Successor: | Mihail Kogălniceanu Lascăr Catargiu |
| Office1: | Minister of Internal Affairs |
| Term Start1: | 24 June 1862 - 11 October 1863 30 January 1866 |
| Term End1: | 11 February 1866 |
| Primeminister1: | himself |
| Predecessor1: | Apostol Arsache Ion Emanuel Florescu |
| Successor1: | Mihail Kogălniceanu] Dimitrie Ghica |
| Office2: | President of the Senate of Romania |
| Term Start2: | 13 December 1889 |
| Term End2: | 9 June 1890 |
| Monarch2: | Carol I |
| Predecessor2: | Ion Emanuel Florescu |
| Successor2: | Ion Emanuel Florescu |
| Birth Date: | 1 March 1812 |
| Birth Place: | Bucharest, Wallachia |
| Death Date: | [1] |
| Death Place: | Leordeni, Argeș County, Kingdom of Romania |
| Resting Place: | Bellu Cemetery, Bucharest |
| Occupation: | Physician, politician |
| Party: | National Liberal Party |
| Children: | Ana Crețulescu-Lahovary |
| Mother: | Ana Anica Câmpineanu de Cantimir |
| Father: | Alexandru Crețulescu |
| Relatives: | Constantin A. Crețulescu, (brothers) |
Prince Nicolae Crețulescu (pronounced as /ro/, surname also spelled Kretzulescu; 1 March 1812 – 26 June 1900) was a Prince Wallachian, later Romanian politician and physician. He is an aristocrat and member of the Kretzulescu family. He served two terms as Prime Minister of Romania: from 1862 to 1863, and from 1865 to 1866. He was elected to the Romanian Academy. He was the 3rd president of the Romanian Academy from 1872 to 1873.
Born in Bucharest, he studied medicine in Paris, having Gustave Flaubert as a colleague. As a physician, his notable work was the translation of Jean Cruveilhier's manual of anatomy.
A member of the Liberal faction, Crețulescu first became prime minister after the assassination of Barbu Catargiu, under ruler Alexandru Ioan Cuza. He avoided debating the issue of land reform, at that time the most contentious subject in Romanian politics; instead, Crețulescu focused on unifying the public health system, creating the Directorate General of the Public Archive, and establishing a Council for Public Instruction. Additionally, he laid the groundwork for further laws secularizing the property of monasteries.