| Official Name: | Nicolás Descalzi |
| Settlement Type: | Locality |
| Established Title: | Founded |
| Established Date: | 1929 |
| Pushpin Map: | Argentina |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Argentina |
| Pushpin Mapsize: | 200 |
| Pushpin Mapsize1: | 200 |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Name1: | Buenos Aires |
| Subdivision Type2: | Partido |
| Subdivision Name2: | Coronel Dorrego |
| Map Location: | Province of Buenos Aires |
| Leader Title: | Intendent |
| Leader Name: | Fabián Andrés Zorzano (Civic Coalition-UCR) |
| Population Total: | Dispersed rural population |
| Population Asof: | 2010 |
| Elevation M: | 148 |
| Utc Offset1: | -03:00 |
| Demographics Type1: | Language |
| Demographics1 Title1: | Spanish |
| Postal Code Type: | Postal code |
| Postal Code: | 8151 |
| Area Code Type: | Telephone code |
| Area Code: | 02921 |
| Coordinates: | -38.4397°N -60.99°W |
Nicolás Descalzi is a rural area in Coronel Dorrego Partido, in the Province of Buenos Aires, Argentina.
It is located 46 km northeast of the city of Coronel Dorrego through a rural road.[1]
The opening of the railway station of the Juan E. Barra - Coronel Dorrego Branch of the Buenos Aires Great Southern Railway in 1929 led to the formation of the town. The subsequent closure of the railway services in 1961 caused the population decline.[2]
In the Argentine censuses of 2001 and 2010, it was counted as a dispersed rural population.
The area gets its name from Nicolás Descalzi, an Italian-Argentine explorer.[3]