Nicodicodine Explained

Watchedfields:changed
Verifiedfields:changed
Verifiedrevid:447732381
Iupac Name:(5alpha,6alpha)-3-Methoxy-17-methyl-4,5-epoxymorphinan-6-yl pyridine-3-carboxylate[1]
Width:210
Alt2:Ball-and-stick model
Width2:220
Legal Au:S2
Legal Au Comment:[2]
Legal Br:A2
Legal Br Comment:[3]
Legal De:Anlage II
Legal De Comment:[4]
Legal Uk:Class B
Legal Uk Comment:[5]
Legal Un:narcotic schedules i and iii
Legal Un Comment:[6]
Routes Of Administration:Oral, intravenous
Cas Number:808-24-2
Atc Prefix:none
Pubchem:5464304
Chemspiderid:4576612
Unii:04G0T06UGT
Synonyms:Nicodicodeine, 6-Nicotinoyldihydrocodeine, Nicodicodina,[7] Nicodicodinum
C:24
H:26
N:2
O:4
Smiles:CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)OC(=O)C6=CN=CC=C6
Stdinchi:InChI=1S/C24H26N2O4/c1-26-11-9-24-16-6-8-19(29-23(27)15-4-3-10-25-13-15)22(24)30-21-18(28-2)7-5-14(20(21)24)12-17(16)26/h3-5,7,10,13,16-17,19,22H,6,8-9,11-12H2,1-2H3/t16-,17+,19-,22-,24-/m0/s1
Stdinchikey:GTGRMWCOZHEYRL-MJFIPZRTSA-N

Nicodicodine is an opioid developed as a cough suppressant and analgesic.[8] Synthesized in 1904, it is not commonly used, but has activity similar to other opioids.[8] Nicodicodine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opioids and include itching, nausea and respiratory depression.

Notes and References

  1. Web site: Chemistry Dashboard . comptox.epa.gov . U.S. Environmental Protection Agency . 10 January 2019.
  2. Web site: Drugs Misuse Regulation 1987 . www.legislation.qld.gov.au . Office of the Queensland Parliamentary Counsel . 10 January 2019.
  3. Web site: Anvisa . Brazilian Health Regulatory Agency . 2023-03-31 . RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial . Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control. live . https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 . 2023-08-03 . 2023-08-03 . . pt-BR . 2023-04-04.
  4. Web site: Anlage II BtMG - Einzelnorm . www.gesetze-im-internet.de.
  5. Web site: Misuse of Drugs Act 1971 . www.legislation.gov.uk . 10 January 2019.
  6. Web site: The International Drug Control Conventions . undocs.org . United Nations . 10 January 2019.
  7. Web site: Nicodicodine [INN:BAN:DCF] SIELC ]. www.sielc.com . 16 May 2018 . 12 January 2019.
  8. Book: Stolberg VB . Painkillers: History, Science, and Issues . 2016 . ABC-CLIO . 978-1-4408-3532-2 . 110 . 12 January 2019 . en.