| Nicanor Restrepo Giraldo | |
| Office: | Mayor of Medellín |
| Predecessor: | Henrique Gaviria |
| Successor: | Alfonso Vieira Jaramillo |
| Termend: | January 1925 |
| Termstart: | February 1924 |
| Office2: | Mayor of Medellín |
| Predecessor2: | Antonio M. Ramírez |
| Successor2: | Jesús Escobar |
| Termend2: | September 1908 |
| Termstart2: | March 1904 |
| Office1: | Governor of Jericó |
| Predecessor1: | Position established |
| Termend1: | 1909 |
| Termstart1: | 1908 |
| Birth Date: | June 1871 |
| Birth Place: | Medellín, Antioquia, Colombia |
| Death Place: | Medellín, Antioquia, Colombia |
| Spouse: | Ana Jesús Correa Correa |
| Occupation: | Businessman; politician |
Nicanor Restrepo Giraldo (June 1871 – 19 May 1938) was a Colombian businessman and politician who served as Mayor of Medellín from 1904 to 1908, and later from 1924 to 1925. He also served as Governor of the now-defunct Department of Jericó from 1908 to 1909.
Restrepo Giraldo was born in June 1871 in Medellín, Colombia, to parents Lisandro Restrepo Arango and Dolores Giraldo Gómez.