| Province: | NL |
| Type: | NL |
| Route: | 461 |
| Maint: | Newfoundland and Labrador Department of Transportation and Infrastructure |
| Length Km: | 21.0 |
| Direction A: | South |
| Terminus A: | near St. George's |
| Junction: | between Barachois Brook and Stephenville Crossing |
| Direction B: | North |
| Terminus B: | in Stephenville Crossing |
| Previous Type: | NL |
| Previous Route: | 460 |
| Next Type: | NL |
| Next Route: | 462 |
Route 461 is a 21adj=midNaNadj=mid north–south highway on the western side of Newfoundland in the Canadian province of Newfoundland and Labrador. It connects the towns of St. George's, Barachois Brook, Mattis Point, and Stephenville Crossing.
Route 461 begins at an intersection with Route 1 (Trans-Canada Highway) and it heads north to enter St. George's, where it makes a sharp right turn onto Main Street in downtown. The highway winds its way northeast through neighbourhoods as it follows the coast before crossing a river into Barachois Brook. Route 461 passes through that town before coming to an intersection with Route 490 (Stephenville Access Road/Katarina Roxon Way), where it becomes concurrent with Route 490 and they head north to have an intersection with a local road leading to Mattis Point. This is the only example of a road concurrency in the entire province of Newfoundland and Labrador. Route 461/Route 490 now cross a bridge over an inlet to enter Stephenville Crossing, where the two highways split at a fork in the road, with Route 461 going straight through downtown along West Street and Brook Street. Route 461 now heads northward through neighbourhoods for a few kilometres to leave town and come to an end shortly thereafter at an intersection with Route 460 (White's Road/Hansen Memorial Highway).