| Province: | NL |
| Type: | NL |
| Route: | 401 |
| Alternate Name: | Howley Road |
| Maint: | Newfoundland and Labrador Department of Transportation and Infrastructure |
| Length Km: | 13 |
| Direction B: | North |
| Terminus B: | east of Deer Lake |
| Direction A: | South |
| Terminus A: | End of asphalt pavement in Howley |
| Previous Type: | NL |
| Previous Route: | 392 |
| Next Type: | NL |
| Next Route: | 402 |
Route 401, also known as Howley Road, is a 13adj=midNaNadj=mid minor highway in the western region of Newfoundland in the Canadian province of Newfoundland and Labrador. The highway begins at a junction with the Trans-Canada Highway (Route 1) and continues to its southern terminus, the community of Howley. There are no other major intersections or communities along the entire length of Route 401. As with most highways in Newfoundland and Labrador, Route 401 is a two-lane highway in its entirety.