| Province: | NL |
| Type: | NL |
| Route: | 345 |
| Maint: | Newfoundland and Labrador Department of Transportation and Infrastructure |
| Length Km: | 16.1 |
| Direction A: | South |
| Terminus A: | in Virgin Arm–Carter's Cove |
| Direction B: | North |
| Terminus B: | Tizzard's Harbour |
| Previous Type: | NL |
| Previous Route: | 344 |
| Next Type: | NL |
| Next Route: | 346 |
Route 345 is a 16.1adj=midNaNadj=mid north-south highway on New World Island in the Canadian province of Newfoundland and Labrador. It connects the communities of Virgin Arm–Carter's Cove with Tizzard's Harbour on the western half of the island.
Route 345 begins in Virgin Arm–Carter's Cove at an intersection with Route 340 (Road to the Isles). It winds its way west through town before leaving and heading northwest through rural areas to pass through Chanceport. The highway now winds its way through wooded and hilly terrain for several kilometres to come to an intersection with a spur road leading to Bridgeport, where it turns north to enter Moreton's Harbour. Route 345 has an intersection with a road leading to Valley Pond before winding its way northeast through town. It heads northeast through rural areas for several more kilometres to enter Tizzard's Harbour, where it comes to an end at the centre of town.