| Province: | NL |
| Type: | NL |
| Route: | 343 |
| Alternate Name: | Road to Comfort Cove |
| Maint: | Newfoundland and Labrador Department of Transportation and Infrastructure |
| Length Km: | 15.6 |
| Direction A: | South |
| Terminus A: | in Campbellton |
| Direction B: | North |
| Terminus B: | Comfort Cove-Newstead |
| Previous Type: | NL |
| Previous Route: | 342 |
| Next Type: | NL |
| Next Route: | 344 |
Route 343, also known as Road to Comfort Cove, is a short north–south highway that leads from Route 340 (Road to the Isles) just east of Campbellton to Comfort Cove-Newstead on the northern coast of the island of Newfoundland in the Canadian province of Newfoundland and Labrador. It is a relatively short highway with no other towns on the route other than Comfort Cove-Newstead. As with most highways in Newfoundland and Labrador, it is entirely a two-lane highway.