| Chamber: | Assembly |
| State: | New York |
| District: | 121 |
| Representative: | Joe Angelino |
| Party: | Republican |
| Residence: | Norwich |
New York's 121st State Assembly district is one of the 150 districts in the New York State Assembly. It has been represented by Republican Joe Angelino since 2023, succeeding John Salka. Prior to redistricting, Angelino represented District 122.
District 121 contains portions of Broome, Chenango, Delaware, Madison, Otsego and Sullivan counties.
This district encompasses the entirety of Madison County and portions of Oneida County and Otsego County.