| Province: | NB |
| Type: | NB |
| Route: | 380 |
| Maint: | New Brunswick Department of Transportation |
| Length Km: | 12 |
| Length Ref: | [1] |
| Length Round: | 1 |
| Direction A: | East |
| Direction B: | West |
| Terminus A: | North-East of Limestone |
| Cities: | Lake Edward, New Denmark Corner, Outlet Brook, Bell Grove, Merritt Lake, Anderson Road, |
| Terminus B: | in Saint Elmo |
| Previous Type: | NB |
| Previous Route: | 375 |
| Next Type: | NB |
| Next Route: | 385 |
Route 380 is a 12km (07miles) long mostly east–west secondary highway in the northwest portion of New Brunswick, Canada.
The route's North-Eastern terminus is north-east of the community of Limestone. The road travels south-east to the community of Lake Edward. The road then takes a sharp turn north to the community of New Denmark Corner. The road again makes a sharp turn this time towards the south-east passing Outlet Brook before entering the community of Bell Grove. The road then switches direction to the south-west again then enters the community of Merritt Lake. After this, the road takes its last major directional change south-east passing the community of Anderson Road before ending in Saint Elmo.