| Province: | NB |
| Type: | NB |
| Route: | 375 |
| Map Custom: | yes |
| Maint: | New Brunswick Department of Transportation |
| Length Km: | 5.4 |
| Length Ref: | [1] |
| Length Round: | 1 |
| Direction A: | East |
| Direction B: | West |
| Terminus A: | in Lower Portage |
| Terminus B: | US Border at the Gillespie Portage becomes |
| Previous Type: | NB |
| Previous Route: | 370 |
| Next Type: | NB |
| Next Route: | 380 |
Route 375 is a 5.4km (03.4miles) long east–west secondary highway in the northwest portion of New Brunswick, Canada.
The route's northeastern terminus is in the community of Lower Portage at Route 130. The road travels west, passing under Route 2 (Trans-Canada Highway) (no direct access), before passing Pines Lake and continuing to the US Border at the Limestone–Gillespie Portage Border Crossing near Limestone, Maine, where it becomes Maine State Route 229.