| Province: | NB |
| Type: | NB |
| Route: | 280 |
| Maint: | New Brunswick Department of Transportation |
| Length Km: | 18 |
| Length Ref: | [1] |
| Length Round: | 1 |
| Established: | 1965 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in McLeods |
| Counties: | Restigouche |
| Cities: | Eel River Crossing, Charlo |
| Junction: | in McLeods in Eel River Crossing |
| Terminus B: | in Charlo |
| Previous Type: | NB |
| Previous Route: | 275 |
| Next Type: | NB |
| Next Route: | 303 |
Route 280 is an 18km (11miles) local highway in northeast New Brunswick, Canada.