| Province: | NB |
| Type: | NB |
| Route: | 161 |
| Maint: | New Brunswick Department of Transportation |
| Length Km: | 5.0 |
| Length Ref: | [1] |
| Length Round: | 1 |
| Established: | 2001 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | in Clair |
| Cities: | Clair, Caron Brook |
| Junction: | in Clair |
| Terminus B: | in Caron Brook |
| Previous Type: | NB |
| Previous Route: | 160 |
| Next Type: | NB |
| Next Route: | 165 |
Route 161 is a New Brunswick highway that runs for 5km (03miles) from a junction with Route 120 at Caron Brook, to the International Bridge at Clair; in Madawaska County. The route connects to U.S. Route 1 and Maine State Route 161 across the Saint John River in Fort Kent, Maine.
Route 161 was part of Route 205 until 1999.