Neurotensin receptor 2 explained

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1] [2] [3]

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[4] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.[5] NTS2 is found mostly in the brain through Northern-blot analysis.Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.

See also

Further reading

External links

Notes and References

  1. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D . Molecular cloning of a levocabastine-sensitive neurotensin binding site . FEBS Letters . 386 . 2–3 . 91–4 . May 1996 . 8647296 . 10.1016/0014-5793(96)00397-3 . 5802578 . free .
  2. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P . Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells . European Journal of Pharmacology . 360 . 2–3 . 265–72 . Nov 1998 . 9851594 . 10.1016/S0014-2999(98)00678-5 .
  3. Web site: Entrez Gene: NTSR2 neurotensin receptor 2.
  4. Web site: Entrez Gene: NTSR2 neurotensin receptor 2 .
  5. Vincent . Jean-Pierre . Mazella . Jean . Kitabgi . Patrick . July 1999 . Neurotensin and neurotensin receptors . Trends in Pharmacological Sciences . 20 . 7 . 302–309 . 10.1016/s0165-6147(99)01357-7 . 0165-6147.