Neuropeptides B/W receptor 2 explained

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.^[1]

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.

See also

• Neuropeptide B/W receptor

Further reading

• O'Dowd BF, Scheideler MA, Nguyen T, etal . The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain . Genomics . 28 . 1 . 84–91 . 1995 . 7590751 . 10.1006/geno.1995.1109 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Shimomura Y, Harada M, Goto M, etal . Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8 . J. Biol. Chem. . 277 . 39 . 35826–32 . 2002 . 12130646 . 10.1074/jbc.M205337200 . free .
• Brezillon S, Lannoy V, Franssen JD, etal . Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 . J. Biol. Chem. . 278 . 2 . 776–83 . 2003 . 12401809 . 10.1074/jbc.M206396200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tanaka H, Yoshida T, Miyamoto N, etal . Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 10 . 6251–6 . 2003 . 12719537 . 10.1073/pnas.0837789100 . 156358 . 2003PNAS..100.6251T . free .
• Mazzocchi G, Rebuffat P, Ziolkowska A, etal . G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades . J. Clin. Endocrinol. Metab. . 90 . 6 . 3466–71 . 2005 . 15797961 . 10.1210/jc.2004-2132 . free .

External links

• Web site: Neuropeptide B/W Receptors: NPBW2 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303175126/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3003 . dead .

Notes and References

1. Web site: Entrez Gene: NPBWR2 neuropeptides B/W receptor 2.