Neuromedin B receptor explained

The neuromedin B receptor (NMBR), now known as BB₁ ^[1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.^[2] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.^[3]

References

1. Web site: Bombesin Receptors: BB₁ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2013-10-04 . https://web.archive.org/web/20131004212700/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956 . dead .
2. Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT . Expression and characterization of cloned human bombesin receptors . Mol. Pharmacol. . 47 . 1 . 10–20 . 1995 . 7838118 .
3. Web site: Entrez Gene: NMBR neuromedin B receptor.

Further reading

• Corjay MH, Dobrzanski DJ, Way JM, etal . Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. . J. Biol. Chem. . 266 . 28 . 18771–9 . 1991 . 10.1016/S0021-9258(18)55129-2 . 1655761 . free .
• Wu JM, Hoang DO, Feldman RI . Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs. . Mol. Pharmacol. . 47 . 4 . 871–81 . 1995 . 7723750 .
• Benya RV, Kusui T, Pradhan TK, etal . Expression and characterization of cloned human bombesin receptors. . Mol. Pharmacol. . 47 . 1 . 10–20 . 1995 . 7838118 .
• Bitar KN, Zhu XX . Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction. . Gastroenterology . 105 . 6 . 1672–80 . 1994 . 8253343 . 10.1016/0016-5085(93)91062-m. free .
• Giladi E, Nagalla SR, Spindel ER . Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. . J. Mol. Neurosci. . 4 . 1 . 41–54 . 1993 . 8391296 . 10.1007/BF02736689 . 20854144 .
• Fathi Z, Benya RV, Shapira H, etal . The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. . J. Biol. Chem. . 268 . 20 . 14622–6 . 1993 . 10.1016/S0021-9258(18)82378-X . 8392057 . free .
• Kane MA, Toi-Scott M, Johnson GL, etal . Bombesin-like peptide receptors in human bronchial epithelial cells. . Peptides . 17 . 1 . 111–8 . 1996 . 8822519 . 10.1016/0196-9781(95)02088-8 . 30893871 .
• Sainz E, Akeson M, Mantey SA, etal . Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. . J. Biol. Chem. . 273 . 26 . 15927–32 . 1998 . 9632639 . 10.1074/jbc.273.26.15927 . free .
• Lee S, Kim Y . Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. . FEBS Lett. . 460 . 2 . 263–9 . 1999 . 10544247 . 10.1016/S0014-5793(99)01346-0 . 46035151 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Matusiak D, Glover S, Nathaniel R, etal . Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. . Am. J. Physiol. Gastrointest. Liver Physiol. . 288 . 4 . G718–28 . 2005 . 15528253 . 10.1152/ajpgi.00156.2004 .

External links

• Web site: Bombesin Receptors: BB₁ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2013-10-04 . https://web.archive.org/web/20131004212700/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956 . dead .