| Specialty: | gastroenterology |
Neurogenic bowel dysfunction (NBD) is the inability to control defecation due to a deterioration of or injury to the nervous system, resulting in faecal incontinence or constipation.[1] It is common in people with spinal cord injury (SCI), multiple sclerosis (MS) or spina bifida.[2]
The gastrointestinal tract has a complex control that relies on coordinated interaction between muscular contractions and neuronal impulses.[3] Faecal incontinence or constipation occurs when there is a problem with the normal bowel functioning; this could be for a variety of reasons. The normal defecation pathway involves contractions of the colon in order to help mix the contents, absorb water and propel the contents along the intestine. This results in the faeces moving from the colon to the rectum.[4] The presence of stool in the rectum causes a reflexive relaxation of the internal anal sphincter, so the contents of the rectum can move in to the anal canal. This causes the conscious feeling of the need to defecate. At a suitable time our brain can send signals causing the external anal sphincter and puborectalis muscles to relax as these are under voluntary control and this allows defecation to take place.[5]
Spinal cord injury and other neurological problems mostly affect the lower GI tract leading to symptoms of incontinence or constipation. However, the upper GI tract may also be affected and patients with neurogenic bowel often present with multiple symptoms.[6] [7] Research shows there is a high prevalence of upper abdominal complaints, for example a study showed that approximately 22% of SCI patients reported feeling bloated [8] and about 31% of SCI patients’ experienced abdominal distension.[9]
Neurogenic bowel dysfunction can have an impact on a person's life as it often leads to difficulties with self-esteem, personal relationships, social life and can also reduce a person's independence. There is also evidence from studies showing that faecal incontinence can increase the risk of depression and anxiety.[10]
Different neurological disorders affect the gastrointestinal tract in different ways:
Bowel dysfunction caused by a spinal cord injury will vary greatly depending on the severity and level of the spinal cord lesion. In complete spinal cord injury both sensory and motor functions are completely lost below the level of the lesion so there is a loss of voluntary control and loss of sensation of the need to defecate. An incomplete spinal cord injury is one where there may still be some sensation or motor function below the level of the lesion.
Colorectal dysfunction due to spinal cord injury can be classified in to two types: an upper motor neuron lesion or lower motor neuron lesion. Problems with the upper motor neuron in a neurogenic bowel results in a hypertonic and spastic bowel because the defecation reflex centre, which causes the involuntary contraction of muscles of the rectum and anus, remains intact. However, the nerve damage results in disruption to the nerve signals and therefore there is an inability to relax the anal sphincters and defecate, often leading to constipation. An upper motor neuron lesion is one that is above the conus medullaris of the spinal cord and therefore above the vertebral level T12.[11] On the other hand, a lower motor neuron lesion can cause areflexia and a flaccid external anal sphincter so most commonly leading to incontinence. Lower motor neuron lesions are damage to nerves that are at the level of or below the conus medullaris and below vertebral level T12. However, both upper and lower motor neuron disorders can lead to constipation and/ or incontinence.[12]
Patients with Spina Bifida have a neural tube that has failed to completely form. This is most commonly in the lower back area in the region of the conus medullaris or cauda equina. It, therefore, affects the bowel similarly to a spinal cord injury affecting the lower motor neuron resulting in a flaccid unreactive rectal wall and means the anal sphincter doesn't contract and close therefore leading to stool leakage. Most patients with spina bifida also have hydrocephalus this can result in intellectual deficits so can contribute to faecal incontinence.
There are a variety of symptoms associated with this condition that are all caused by a loss of myelin, the insulating layer surrounding the neurones. This means the nerve signals are interrupted and slower which will then cause muscle contractions to be fewer and irregular resulting in an increased colon transit time. The faeces being in the colon for a longer time will mean that more water is absorbed leading to harder stools and therefore increasing the symptoms of constipation. This neurological problem can also lead to reduced sensation of rectal filling and weakness of the anal sphincter because of weak muscular contraction so can cause stool leakage. In patients with multiple sclerosis constipation and faecal incontinence often coexist and they can be acute, chronic or intermittent due to the fluctuating pattern of MS.
Damage to the defecation centre within the medulla oblongata of the brain can lead to bowel dysfunction. A stroke or acquired brain injury may lead to damage to this centre in the brain. Damage to the defecation centre can lead to a loss of coordination between rectal and anal contractions and also a loss of awareness of the need to defecate.
This condition differs as it affects both the extrinsic and enteric nervous systems due to the decreased dopamine levels in both. This results in less smooth muscle contraction of the colon, increasing the colon transit time. The reduced dopamine levels also causes dystonia of the striated muscles of the pelvic floor and external anal sphincter. This explains how Parkinson's disease can lead to constipation.
Twenty percent of people with diabetes mellitus experience faecal incontinence due to irreversible autonomic neuropathy. This is due to the high blood glucose levels over time damaging the nerves, which can lead to impaired rectal sensation.
There are different types of neurons involved in innervating the lower GI tract these include: the enteric nervous system; located within the wall of the gut, and the extrinsic nervous system; comprising sympathetic and parasympathetic innervation. The enteric nervous system directly controls the gut motility, whereas, the extrinsic nerve pathways influence gut contractility indirectly through modifying this enteric innervation. In almost all cases of neurogenic bowel dysfunction it is the extrinsic nervous supply affected and the enteric nervous supply remains intact. The only exception being Parkinson's disease, as this can affect both the enteric and extrinsic innervation.[13]
Defecation involves conscious and subconscious processes, when the extrinsic nervous system is damaged either of these can be affected. Conscious processes are controlled by the somatic nervous system, these are voluntary movements for example the contraction of the striated muscle of the external anal sphincter is instructed to do so by the brain, which sends signals along the nerves innervating this muscle.[14] [15] Subconscious processes are controlled by the autonomic nervous system; these are involuntary movements such as contraction of the smooth muscle of the internal anal sphincter or the colon. The autonomic nervous system also provides sensory information; this could be about the level of distension within the colon or rectum.
Management and treatment for neurogenic bowel dysfunction depends on symptoms and biomedical diagnosis for cause of the condition. General practitioners will often refer patients to gastroenterologist to effectively manage the neurogenic bowel dysfunction. Research has been conducted on a variety of therapy and treatments for neurogenic bowel dysfunction including: diet modification, laxatives, magnetic and electrical stimulation, manual evacuation of feces and abdominal massage, enemas, and pulsed irrigation evacuation (PIE).[19] [20] Efficacy studies for pulsed irrigation evacuation with PIEMED demonstrated favorable results, removing stool of 98% of patients who used it for ineffective bowel routine, symptomatic impaction, or asymptomatic impaction. In the most severe of cases of neurogenic bowel dysfunction induced fecal impaction, surgical interventions like colostomy are used to disrupt the dense mass of stool.[21] [22]