NeuroD explained

NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.^[1] It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.^[2]

In mammals there are two types of this factor:

• NeuroD1
• NeuroD2
• NeuroD4
• NeuroD6

Notes and References

1. Gu . Chunyan . Stein . Gretchen H. . Pan . Ning . Goebbels . Sandra . Hörnberg . Hanna . Nave . Klaus-Armin . Herrera . Pedro . White . Peter . Kaestner . Klaus H. . Sussel . Lori . Lee . Jacqueline E. . Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity . Cell Metabolism . 7 April 2010 . 11 . 4 . 298–310 . 10.1016/j.cmet.2010.03.006 . 20374962 . 2855640 . en . 1550-4131. free .
2. Morrow . E.M. . Furukawa . T. . Lee . J.E. . Cepko . C.L. . NeuroD regulates multiple functions in the developing neural retina in rodent . Development . 1 January 1999 . 126 . 1 . 23–36 . 10.1242/dev.126.1.23 . 9834183 . 1 March 2022.