| Games: | Central American and Caribbean Games |
| Year: | 2010 |
| Noc: | AHO |
| Location: | Mayagüez, Puerto Rico |
| Competitors: | 99 |
| Competitors Men: | 75 |
| Competitors Women: | 24 |
| Sports: | 12 |
| Flagbearer: | Anne-Marie Pietersz |
| Gold: | 2 |
| Silver: | 3 |
| Bronze: | 2 |
| Rank: | 13 |
The Netherlands Antilles sent 99 athletes (75 males, 24 females)[1] to the XXIst Central American and Caribbean Games in Mayagüez, Puerto Rico, July 17 - August 1, 2010.[2]
The athletes participated in athletics (6), baseball (20), bowling (3), boxing (1), (field) hockey (16), judo (3), karate do (3), sailing (6), shooting (6), softball (17), swimming (3), and water polo (13).
See main article: Swimming at the 2010 Central American and Caribbean Games.