Methazolamide Explained

Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.

This drug has displayed teratogenic effects in rats. Compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.

References

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• Web site: RxList . Neptazane . August 20, 2006 . https://web.archive.org/web/20060812234553/http://www.rxlist.com/cgi/generic2/methaz.htm . August 12, 2006 . dead .
• Shirato S, Kagaya F, Suzuki Y, Joukou S . Stevens–Johnson syndrome induced by methazolamide treatment. . Arch Ophthalmol . 115 . 4 . 550 - 3 . 1997 . 9109770 . 10.1001/archopht.1997.01100150552021.
• Skorobohach B, Ward D, Hendrix D . Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs. . Am J Vet Res . 64 . 2 . 183 - 7 . 2003 . 12602587 . 10.2460/ajvr.2003.64.183. free .