Neomycin C transaminase explained

Neomycin C transaminase
Ec Number:	2.6.1.95

Neomycin C transaminase (neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons 6'''-deamino-6'''-oxoneomycin C + L-glutamate

The reaction occurs in vivo in the opposite direction.

Notes and References

1. Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB . Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin . ChemBioChem . 8 . 3 . 283–8 . February 2007 . 17206729 . 10.1002/cbic.200600371 .
2. Clausnitzer D, Piepersberg W, Wehmeier UF . The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin . Journal of Applied Microbiology . 111 . 3 . 642–51 . September 2011 . 21689223 . 10.1111/j.1365-2672.2011.05082.x .