| neolactotetraosylceramide alpha-2,3-sialyltransferase | |
| Ec Number: | 2.4.99.10 |
| Cas Number: | 83745-06-6 |
| Go Code: | 0004513 |
In enzymology, a neolactotetraosylceramide alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D- galactosyl-1,4-D-glucosylceramide
\rightleftharpoons
The 3 substrates of this enzyme are CMP-N-acetylneuraminate, beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-, and galactosyl-1,4-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-, and glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-neolactotetraosylceramide, sialyltransferase, sialyltransferase 3, and SAT-3. This enzyme participates in glycosphingolipid biosynthesis - neo-lactoseries and glycan structures - biosynthesis 2.