Neil Brockdorff Explained

Neil Brockdorff
Birth Name:Neil Alexander Steven Brockdorff
Fields:Developmental epigenetics
X inactivation[1]
Workplaces:University of Oxford
Education:Hampstead School
Alma Mater:University of Sussex (BSc)
University of Glasgow (PhD)[2]
Thesis Title:The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus
Thesis Url:https://copac.jisc.ac.uk/id/7972130?style=html
Thesis Year:1985
Doctoral Advisors:)-->
Awards:EMBO Member (1999)[3]
Spouses:)-->
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Neil Alexander Steven Brockdorff [4] (born 1958) is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.[5] [6] Brockdorff's research investigates gene and genome regulation in mammalian development. His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.[7]

Education

Brockdorff was educated at Hampstead School, the University of Sussex (BSc) and the University of Glasgow (PhD).[2]

Career and research

X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.[7] [8] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.[9] [10] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.[7] [11] [12]

Awards and honours

Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).

Notes and References

  1. Brockdorff. Neil. Polycomb complexes in X chromosome inactivation. Philosophical Transactions of the Royal Society B. 372. 1733. 2017. 0962-8436. 10.1098/rstb.2017.0021. 28947664 . 5627167 .
  2. Neil Alexander Steven. Brockdorff. The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus. . 301485805. University of Glasgow. 1985. PhD. jisc.ac.uk.
  3. Web site: EMBO MEMBER: Neil Brockdorff. people.embo.org. 12 June 2018.
  4. Web site: Professor Neil Brockdorff - The Academy of Medical Sciences. acmedsci.ac.uk. 12 June 2018.
  5. Web site: Brockdorff Lab. sites.google.com. 12 June 2018.
  6. Web site: Prof Neil Brockdorff Page - Department of Biochemistry, University of Oxford. www.bioch.ox.ac.uk. 12 June 2018.
  7. Web site: Professor Neil Brockdorff FRS. https://web.archive.org/web/20180606144124/https://royalsociety.org/people/neil-brockdorff-13800/. 2018-06-06. royalsociety.org. Royal Society. Anon. 2018. London. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  8. de Napoles. Mariana. Mermoud. Jacqueline E.. Wakao. Rika. Tang. Y.Amy. Endoh. Mitusuhiro. Appanah. Ruth. Nesterova. Tatyana B.. Silva. Jose. Otte. Arie P.. Vidal. Miguel. Koseki. Haruhiko. Brockdorff. Neil. Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation. Developmental Cell. 7. 5. 2004. 663–676. 1534-5807. 10.1016/j.devcel.2004.10.005. 15525528. free.
  9. Penny. Graeme D.. Kay. Graham F.. Sheardown. Steven A.. Rastan. Sohaila. Brockdorff. Neil. Requirement for Xist in X chromosome inactivation. Nature. 379. 6561. 1996. 131–137. 0028-0836. 10.1038/379131a0. 8538762. 1996Natur.379..131P. 4329368.
  10. Brockdorff. Neil. Ashworth. Alan. Kay. Graham F.. McCabe. Veronica M.. Norris. Dominic P.. Cooper. Penny J.. Swift. Sally. Rastan. Sohaila. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell. 71. 3. 1992. 515–526. 0092-8674. 10.1016/0092-8674(92)90519-I. 1423610. 19889657.
  11. Heard. Edith. Edith Heard. Brockdorff. Neil. Preface: X-chromosome inactivation and Mary Lyon. Philosophical Transactions of the Royal Society B. 372. 1733. 2017. 0962-8436. 10.1098/rstb.2016.0353. 28947653 . 5627156 .
  12. Stock. Julie K.. Giadrossi. Sara. Casanova. Miguel. Brookes. Emily. Vidal. Miguel. Koseki. Haruhiko. Brockdorff. Neil. Fisher. Amanda G.. Pombo. Ana. Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nature Cell Biology. 9. 12. 2007. 1428–1435. 1465-7392. 10.1038/ncb1663. 18037880. 10261/61600. 2317691. free.

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