| Nefise Hatun | |
| Issue: | Mehmed II of Karaman Alaeddin Ali II of Karaman Oğuz Bey |
| Full Name: | Nefise Melek Sultan Hatun |
| House: | Ottoman (by birth) Karamanid (by marriage) |
| Father: | Murad I |
| Birth Place: | Bursa, Ottoman Empire |
| Death Date: | after 1402 |
| Death Place: | Mut, Karamanid Principality |
| Religion: | Sunni Islam |
Nefise Melek Sultan Hatun (Turkish, Ottoman (1500-1928);: نفیسہ خاتون; "precious" and "angel"; - after 1402) was an Ottoman princess, the daughter of Sultan Murad I of the Ottoman Empire. She was the wife of Alaeddin Ali Bey of Karaman, the ruler of Karamanids, the mother of the next Karamanid ruler, Mehmed II of Karaman and the first political active Ottoman princess known.
Her father served her to try to calm Alaeddin Bey, the son and successor of Halil Bey, ruler of Karamanids. He therefore married her to him in 1378. After the marriage, Nefise became known as Sultan Hatun. In the early days of the reign of Murad, Alaeddin, tried to increase the embarrassment that the revolt of the landowners of Galatia had raised Murad, and to encourage the insurrection by a diversion powerful, excited the Warsaks to join the rebels' Angora; but the capture of the city and wedding of Nefise Hatun, Murad with Alaeddin, restored peace for some time. From that moment, the envious Alaeddin sought every opportunity to break the treaty which united the ruler of the Ottomans.
As seen, the union did not have the desired effect. Therefore, to resume hostilities with the participation of two of the sons of Murad I, Yakub Çelebi and Bayezid, therefore, brethren Nefise. Defeated, Alaeddin took refuge in Konya. To get out of this mess, he sent Nefise and their children to her father, to ask for forgiveness from the Sultan.
According to Joseph von Hammer-Purgstall:
Alphonse de Lamartine tells the scene with more details:
In 1387 Nefise built the Theological College of Karaman.
Nefise tried to maintain peace between her husband and her brother Bayezid I, who became sultan upon Murad's death in 1389, but she failed: in 1397 her men faced each other in the Battle of Akçay and Alaeddin was killed, making Nefise a widow. Bayezid I ordered her to return to Bursa with her children. However, upon Bayezid's capture by Timur in 1402, she returned to Karaman, where her eldest son, Mehmed, became ruler.
Nefise died after 1402 to Karaman.
By her marriage, she at least had three sons: