| Neffsville, Pennsylvania | |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Pennsylvania#USA |
| Pushpin Label: | Neffsville |
| Pushpin Label Position: | top |
| Pushpin Map Caption: | Location in Pennsylvania##Location in the United States |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Pennsylvania |
| Subdivision Type2: | County |
| Subdivision Name2: | Lancaster |
| Subdivision Type3: | Township |
| Subdivision Name3: | Manheim |
| Unit Pref: | Imperial |
| Population As Of: | 2000 |
| Population Density Km2: | auto |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Coordinates: | 40.1°N -76.3056°W |
| Postal Code Type: | ZIP Codes |
| Postal Code: | 17601 |
| Area Code: | 717 |
| Blank Name: | FIPS code |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 1182217 |
Neffsville is an unincorporated community in Manheim Township, Lancaster County, Pennsylvania, United States. As an unincorporated area, Neffsville has no formalized boundaries. The U.S. Geological Survey locates Neffsville at 40°6'0"N 76°18'20"W.
The retail and restaurant center of Neffsville is near 2500 Lititz Pike (Pennsylvania Route 501). Lancaster, the county seat, is to the south, and Lititz is 4miles to the north. Pennsylvania Route 722 leads west 3miles to East Petersburg and east 3miles to Pennsylvania Route 272 at Oregon.
Manheim Township School District serves 5,400 students with 637 employees, 423 of them holding teaching certificates. Manheim Township High School on School Road is considered to be in Neffsville.
According to local tradition, Neffsville was named for the family of Johan Christian Neff, originally from Gerolsheim, Germany, who was aboard the ship Lydia when she arrived in Philadelphia on September 19, 1743. Neff moved to Lampeter Township in Lancaster County, married the former Frena Howery, and they had three children there - Christian in 1750, Henry in 1754, and Esther in 1757. All three married in Lancaster County, but Christian's life ended in Westmore County, and Esther's in Lebanon County. An elementary school on School Road was named for Henry Holt.
Jacob Shank, a Neffsville pharmacist, introduced "Shank's Compound Flavoring of Vanilla Bean" in 1899 to improve the taste of his medicines. The product is still made today, and Shank's is now the second-largest primary vanilla supplier in North America, as well as supplying other extracts, flavorings and spices. The Shanks family sold the business in 1959, and it is no longer in Neffsville, but many collectors prize their old extract bottles that read "Shank's Extracts - Neffsville, Pa."
Neffsville appears in the animated movie Free Birds.