Necrobiosis Explained

Necrobiosis
Field:Pathology

Necrobiosis is the physiological death of a cell, and can be caused by conditions such as basophilia, erythema, or a tumor. It is identified both with[1] and without necrosis.

Necrobiotic disorders are characterized by presence of necrobiotic granuloma on histopathology. Necrobiotic granuloma is described as aggregation of histiocytes around a central area of altered collagen and elastic fibers. Such a granuloma is typically arranged in a palisaded pattern.[2]

It is associated with necrobiosis lipoidica and granuloma annulare.

Necrobiosis differs from apoptosis, which kills a damaged cell to protect the body from harm.

Notes and References

  1. http://www.emedicine.com/asp/dictionary.asp?keyword=Necrobiosis eMedicine/Stedman Medical Dictionary Lookup
  2. Pokharel . Achyut . Koirala . Isha Poudel . 22 May 2018 . Necrobiotic granuloma: An update . Indian Journal of Dermatopathology and Diagnostic Dermatology . 5 . 1 . 27–33 . 10.4103/ijdpdd.ijdpdd_12_18. 81162412 . free .