| State: | NE |
| Type: | NE |
| Route: | 53 |
| Map: | Nebraska Highway 53 map.png |
| Map Notes: | Nebraska Highway 53 highlighted in red |
| Length Mi: | 12.04 |
| Length Ref: | [1] |
| Length Round: | 2 |
| Established: | January 1, 1975[2] |
| Direction A: | South |
| Terminus A: | east of Gilead |
| Direction B: | North |
| Terminus B: | west of Daykin |
| Counties: | Thayer |
| Previous Type: | NE |
| Previous Route: | 52 |
| Next Type: | NE |
| Next Route: | 56 |
Nebraska Highway 53 is a highway in southern Nebraska. It is a north - south highway which runs for 12miles. It has a southern terminus at U.S. 136 east of Gilead, and a northern terminus west of Daykin at Nebraska Highway 4.
Nebraska Highway 53 begins one mile (1.6 km) east of Gilead at U.S. 136. It proceeds north through farmland and crosses the Little Blue River before entering Alexandria. From Alexandria, it continues north until NE 4, where it ends.[1]
Highway 53 was originally numbered Highway 76 until January 1, 1975, when it was redesignated to avoid confusion with Interstate 76 (formerly Interstate 80S).[3]