| State: | NE |
| Type: | NE |
| Route: | 46 |
| Map: | Nebraska Highway 46 map.png |
| Map Notes: | Nebraska Highway 46 highlighted in red |
| Length Mi: | 12.00 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1926[2] |
| Direction A: | South |
| Terminus A: | west of Stamford |
| Junction: | in Oxford |
| Direction B: | North |
| Terminus B: | north of Oxford |
| Counties: | Furnas, Harlan |
| Previous Type: | NE |
| Previous Route: | 45 |
| Next Type: | NE |
| Next Route: | 47 |
Nebraska Highway 46 is a highway in Nebraska. It runs from south to north for a length of 12miles. It has a southern terminus at Nebraska Highway 89 west of Stamford. It has a northern terminus at U.S. Highway 6 and U.S. Highway 34 north of Oxford.
Nebraska Highway 46 begins at Nebraska Highway 89 west of Stamford. It goes north and meets U.S. Highway 136 in Oxford. They overlap through Oxford and separate on the eastern edge of Oxford. After a brief northwesterly section, the highway turns north at the Furnas County/Harlan County border and ends when it meets U.S. 6 and U.S. 34 north of Oxford.[1]