| State: | NE |
| Type: | NE |
| Route: | 45 |
| Map: | Nebraska Highway 45 map.png |
| Map Notes: | Nebraska Highway 45 highlighted in red |
| Length Mi: | 27.08 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1974[2] |
| Direction A: | South |
| Terminus A: | NE 91 south of Newman Grove |
| Junction: | NE 32 north of Newman Grove |
| Direction B: | North |
| Terminus B: | US 275 in Tilden |
| Counties: | Platte, Madison, Boone, Antelope |
| Previous Type: | NE |
| Previous Route: | 44 |
| Next Type: | NE |
| Next Route: | 46 |
Nebraska Highway 45 is a highway in Nebraska. It runs in a south-to-north direction for 27miles. It has a southern terminus at Nebraska Highway 91 south of Newman Grove. It has a northern terminus in Tilden at an intersection with U.S. Highway 275.
Nebraska Highway 45 begins at Nebraska Highway 91 south of Newman Grove. It goes north through Newman Grove and then meets Nebraska Highway 32. The two highways overlap for 5miles, going north and west to the border between Madison County and Boone County. At the border, Highway 45 turns north and separates from Highway 32. Highway 45 continues north, serving as the west border of Madison County and the east border of Boone County and Antelope County, ending in Tilden at U.S. Highway 275.[1]