| State: | NE |
| Type: | NE |
| Route: | 43 |
| Map: | Nebraska Highway 43 map.png |
| Map Notes: | Nebraska Highway 43 highlighted in red |
| Length Mi: | 30.22 |
| Length Ref: | [1] |
| Direction A: | South |
| Terminus A: | northeast of Adams |
| Junction: | concurrent between Bennet and Palmyra |
| Direction B: | North |
| Terminus B: | in Eagle |
| Counties: | Gage, Lancaster, Otoe, Cass |
| Previous Type: | NE |
| Previous Route: | 41 |
| Next Type: | NE |
| Next Route: | 44 |
Nebraska Highway 43 (N-43) is a highway in southeastern Nebraska. It runs for a length of 30miles in a south-to-north direction. Its southern terminus is near Adams at an intersection with N-41. Its northern terminus is at an intersection with U.S. Highway 34 (US 34) in Eagle.
Nebraska Highway 43 begins near Adams at an intersection with N-41. The highway heads due north into farmland until Bennet. Shortly after Bennet, the highway meets N-2. N-2 and N-43 overlap until Palmyra, which is where N-43 turns north. N-43 goes north for four miles (6 km), west for one, and then north for three more miles, where it meets US 34 in Eagle and ends.[1]