| State: | NE |
| Type: | NE |
| Route: | 121 |
| Map: | Nebraska Highway 121 map.png |
| Map Notes: | Nebraska Highway 121 highlighted in red |
| Length Mi: | 55.03 |
| Length Ref: | [1] |
| Section1: | Southern segment |
| Length Mi1: | 13.51 |
| Direction A1: | South |
| Direction B1: | North |
| Terminus A1: | west of Madison |
| Terminus B1: | north of Battle Creek |
| Section2: | Middle segment |
| Length Mi2: | 28.33 |
| Direction A2: | South |
| Direction B2: | North |
| Terminus A2: | northwest of Pierce |
| Junction2: | in Osmond |
| Terminus B2: | east of Bloomfield |
| Section3: | Northern segment |
| Length Mi3: | 13.19 |
| Direction A3: | South |
| Direction B3: | North |
| Terminus A3: | west of Crofton |
| Terminus B3: | northeast of Crofton |
| Counties: | Southern segment: Madison Middle segment: Pierce, Knox Northern segment: Knox, Cedar |
| Previous Type: | NE |
| Previous Route: | 116 |
| Next Type: | NE |
| Next Route: | 128 |
Nebraska Highway 121 is a highway in northeastern Nebraska. It is a discontinuous highway with three segments:
The southern segment of Nebraska Highway 121 begins at an intersection with NE 32 west of Madison. It heads in a northward direction through farmland, passing through Battle Creek. Just north of Battle Creek, it intersects with US 275, where this segment terminates for about 15miles.[1]
The middle segment of Nebraska Highway 121 begins at NE 13 northwest of Pierce. It heads in a northward direction through farmland, where it intersects with US 20 in Osmond. NE 121 runs concurrently with US 20 for about 3.5miles to the east, before splitting and continuing northward. It then intersects NE 59 before entering Wausa to the north. The highway turns to the east and then northward again as it passes through Wausa. Further north, it will meet NE 84 and the segment will terminate at that point, resuming about 10miles to the northeast.[1]
The third segment of Nebraska Highway 121 begins at NE 12 in Crofton. It heads northward from Crofton through farmland, passing by the Lewis and Clark State Recreation Area and Gavins Point Dam. At that point, the highway turns to the northeast and finally directly eastward. It meets with US 81 south of the South Dakota border and just a couple of miles south of Yankton. NE 121 terminates at US 81.[1]