| State: | NE |
| Type: | NE |
| Route: | 110 |
| Map: | Nebraska Highway 110 map.png |
| Map Notes: | Nebraska Highway 110 highlighted in red |
| Length Mi: | 2.26 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1936[2] |
| Direction A: | South |
| Terminus A: | west of Dakota City |
| Direction B: | North |
| Terminus B: | west of South Sioux City |
| Counties: | Dakota |
| Previous Type: | NE |
| Previous Route: | 109 |
| Next Type: | NE |
| Next Route: | 112 |
Nebraska Highway 110 is a highway in northeastern Nebraska. Its southern terminus is at Nebraska Highway 35 west of Dakota City, and its northern terminus is at U.S. Highway 20 west of South Sioux City.
Nebraska Highway 110 begins at an intersection with NE 35 west of Dakota City. The route heads directly northward through farmland for its short route of 2.26miles, crossing a BNSF Railway line along the way. N-110 terminates at an intersection with US 20.[1]