| State: | NE |
| Type: | NE |
| Route: | 109 |
| Map: | Nebraska Highway 109 map.png |
| Map Notes: | Nebraska Highway 109 highlighted in red |
| Length Mi: | 16.07 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1935[2] |
| Direction A: | South |
| Terminus A: | in Wahoo |
| Direction B: | North |
| Terminus B: | south of Fremont |
| Counties: | Saunders |
| Previous Type: | NE |
| Previous Route: | 105 |
| Next Type: | NE |
| Next Route: | 110 |
Nebraska Highway 109 is a highway in eastern Nebraska. Its southern terminus is at U.S. Highway 77 and Nebraska Highway 92 at Wahoo, Nebraska. Its northern terminus is at U.S. Highway 77 near Fremont, Nebraska.
The route goes north from its intersection with US 77 and NE 92 and heads into farmland, passing through Colon. At Cedar Bluffs, NE 109 meets Nebraska Spur 78H and turns east. It continues east until ending at US 77 south of Fremont.[1]