| State: | NE |
| Type: | NE |
| Route: | 105 |
| Map: | Nebraska Highway 105 map.png |
| Map Notes: | Nebraska Highway 105 highlighted in red |
| Length Mi: | 32.85 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1936[2] |
| Direction A: | South |
| Terminus A: | south of Humboldt |
| Junction: | in Humboldt south of Johnson |
| Direction B: | North |
| Terminus B: | west of Brock |
| Counties: | Richardson, Pawnee, Nemaha |
| Previous Type: | NE |
| Previous Route: | 103 |
| Next Type: | NE |
| Next Route: | 109 |
Nebraska Highway 105 (N-105) is a 32.85miles state highway in Richardson, Pawnee, and Nemaha counties in Nebraska, United States. Its southern terminus is at an intersection with Nebraska Highway 8 south of Humboldt. Its northern terminus is at an intersection with Nebraska Highway 67 west of Brock.
Nebraska Highway 105 begins at an intersection with NE 8 south of Humboldt. It heads in a northbound direction through farmland, turning slightly to the northeast before entering Humboldt. At the north edge of the city, the highway meets with NE 4 and runs concurrently to the west for about 3.5miles. At that point, NE 105 splits and heads directly to the north. It passes by NE 62 east of Elk Creek. Further north, it intersects with US 136 and runs concurrently northward for about a mile. NE 105 continues to the north near Johnson. To the north of Johnson, the highway meets its termination point at NE 67 west of Brock.[1]