| Santa María Nduayaco | |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Population As Of: | 2010 |
| Population Total: | 550 |
| Population Urban: | 57 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 17.4103°N -97.4972°W |
Santa María Nduayaco is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km². It is part of the Teposcolula District in the center of the Mixteca Region.
As of the 2010 census, the town, which serves as the municipal seat, had a population of 57 inhabitants, while the municipality had a total population of 550 inhabitants.[1] Its municipal seat is the second-smallest (to Santa María del Rosario) in all of Mexico.