Natural antisense short interfering RNA explained

Natural antisense short interfering RNA (natsiRNA) is a type of siRNA. They are endogenous RNA regulators which are between 21 and 24 nucleotides in length, and are generated from complementary mRNA transcripts which are further processed into siRNA.[1]

natsiRNA has been implicated in several developmental and response mechanisms in plants, such as pathogen resistance,[2] salt tolerance [3] and cell wall biosynthesis.[4] natsiRNA has also been shown to alter gene expression in plants responding to environmental stressors.[5]

Notes and References

  1. Moldovan . D. . Spriggs . A. . Dennis . E. S. . Wilson . I. W. . The hunt for hypoxia responsive natural antisense short interfering RNAs . Plant Signaling & Behavior . 5 . 3 . 247–251 . 2010 . 20009576 . 2881268 . 10.4161/psb.5.3.10548 . 2010PlSiB...5..247M .
  2. Katiyar-Agarwal . S. . Morgan . R. . Dahlbeck . D. . Borsani . O. . Villegas . A. . Zhu . J. -K. . Staskawicz . B. J. . Jin . H. . A pathogen-inducible endogenous siRNA in plant immunity . 10.1073/pnas.0608258103 . Proceedings of the National Academy of Sciences . 103 . 47 . 18002–18007 . 1693862 . 2006 . 17071740 . free . 2006PNAS..10318002K .
  3. Borsani . O. . Zhu . J. . Verslues . P. E. . Sunkar . R. . Zhu . J. K. . Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis . 10.1016/j.cell.2005.11.035 . Cell . 123 . 7 . 1279–1291 . 2005 . 3137516 . 16377568 .
  4. Held . M. A. . Penning . B. . Brandt . A. S. . Kessans . S. A. . Yong . W. . Scofield . S. R. . Carpita . N. C. . Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley . 10.1073/pnas.0809408105 . Proceedings of the National Academy of Sciences . 105 . 51 . 20534–20539 . 2603254 . 2008 . 19075248 . free . 2008PNAS..10520534H .
  5. Zhang. Xiaoming. Xia. Jing. Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. 22 March 2012. Genome Biology. 13. 20. 10.1186/gb-2012-13-3-r20. 3439971. 22439910. R20 . free .

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