| Country: | CRI |
| Type: | Secondary |
| Route: | 221 |
| Map Custom: | yes --> |
| Direction A: | NORTH/SOUTH/EAST/WEST? |
| Direction B: | NORTH/SOUTH/EAST/WEST? |
| Terminus B: | --> |
| Provinces: | San José, Cartago |
| Length Km: | 7.965 |
| Length Round: | 2 |
| Previous Type: | RNS |
| Previous Route: | 220 |
| Next Type: | RNS |
| Next Route: | 222 |
National Secondary Route 221, or just Route 221 (Spanish; Castilian: Ruta Nacional Secundaria 221, or Spanish; Castilian: Ruta 221) is a National Road Route of Costa Rica, located in the San José, Cartago provinces.[1]
In San José province the route covers Curridabat canton (Curridabat, Granadilla, Sánchez districts).
In Cartago province the route covers La Unión canton (Tres Ríos, Concepción, Dulce Nombre districts).