National Dope Testing Laboratory Explained

The National Dope Testing Laboratory (NDTL) is a premier analytical testing & research organization established as an autonomous body under the Ministry of Youth Affairs and Sports, Government of India. It is the only laboratory in the country responsible for human sports dope testing. It is headed by Chief Executive Officer (CEO). Dr. Puran Lal Sahu is the Scientific Director of NDTL.[1]

It is accredited by National Accreditation Board for Testing & Calibration Laboratories, NABL (ISO/IEC 17025:2017) for human dope testing of urine & blood samples from human sports. NDTL is one of the 29 WADA accredited laboratories in the world. It is one of the modern & state of the art laboratory in the country equipped with latest analytical instrumentation.[2]

Introduction

The NDTL in India was established in 2008 with an aim to get permanently accredited by International Olympic Committee (IOC) and World Anti Doping Agency to do the testing for the banned drugs in human sports. The Lab has successfully completed sample testing for numerous major International as well National events since its inception. The lab was earlier located in the Jawaharlal Nehru Stadium and is shifted to the new site within its stadium complex at New Delhi on May 14, 2009 with better facilities. The area of the new NDTL lab is 2700 square meters as against the earlier area of only 900 square meters.

Accreditation

NDTL is accredited by various National and International agencies to carry out human dope testing. Some of the organizations that accredited NDTL are as follows:[3]

History

Research Projects

NDTL has state of arts facilities for research and is engaged in conducting research on various projects.[6] The research paper is presented in various National and International conferences and published in indexed journals. The first ever Ph.D. thesis : "Detectability of Indian glucocorticosteroid preparations in sports persons: Effect on the endogenous steroid profile" was submitted in April 2009 by Madhusudhana I.Reddy and degree has been awarded.

  1. Detectability of Corticosteroid in various Indian preparations: Effect on Endogenous steroid profile.
  2. Characteristics of IEF Patterns and SDS-PAGE Result of Indian EPO Biosimilars.[7]
  3. Establishing Reference Range for Endogenous Steroids in Indian Sportspersons and to study the effect of ethnicity and steroid abuse on delta values of endogenous steroids.
  4. Analytical strategies in the development and utilization of mass spectrometric method for analysis of Stimulants & Narcotics.
  5. Effect of Ethnicity and Anabolic Steroid Abuse on Delta Value of Endogenous Steroids.
  6. Rapid Screening in Doping Analysis: Separation and Detection of Doping Agents be Liquid and Gas Chromatographic Mass Spectrometric Analysis.
  1. Detection of Synthetic glucocortico steroids, stimulants and anabolic steroids in Indian herbal drugs and supplements.
  2. Discrimination of biological and synthetic origin of anabolic steroids in human urine: Correlation between GCMSD & Isotope Ratio Mass Spectrometry.
  3. An Analytical approach for the Screening of Performance Enhancing Substances from various Dietary Supplements & to study their excretion profile using Chromatographic-Mass Spectrometric Technique.
  4. Development of analytical tools for the Detection and Identification of performance enhancing Peptides in Biological Specimen.
  5. An analytical approach for the Detection of Corticosteroids in Human and Horse Biological Specimen using Chromatographic and Mass Spectrometric Technique.
  6. To study the effect of various preparation of Testosterone on Steroid Profiling and Delta Value of 13C/12C of Testosterone Metabolite in volunteers with Normal/Abnormal Testosterone/ Epitestosterone (T/E) Ratio.
  7. Indian Herbal Drugs : Identification of stimulants, narcotics and other substances with potential of ergogenic aids in sports.
  8. Characterization of physiochemical properties and analysis of liposomes in human biological samples using hyphenated analytical technique.
  9. Detection of Stanozolol conjugated metabolites by liquid chromatography tandem-mass spectrometry.
  10. Prednisone excretion study and identification of its marker metabolites.
  11. Rapid determination of urinary phthalates using liquid chromatography tandem mass spectrometry.
  12. Identification of various banned small peptides in human urine using liquid chromatography tandem mass spectrometry.

Instruments and Technologies

The National Dope Testing Laboratory is equipped with state of the art technologies and the most modern equipment.[8]

The use of Gas Chromatography coupled with Mass Spectrometry (GC-MS) is the most common and the oldest technology being used worldwide for dope testing . Nowadays, the use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has become quite widespread . This technique has helped detect the difficult drugs falling into various categories of banned substances and is becoming increasingly more important in the fight against doping. Apart from GC-MS and LC-MS/MS, the use of Gas Chromatography coupled with tandem Mass Spectrometry (GC-MS/MS) and Isotope-ratio mass spectrometry (IRMS) is also very prevalent in sports dope testing.

Both GC-MS/MS and LC-MS/MS are used primarily to analyze urine samples. The analysis of the blood matrix requires a completely different type of equipment which is commonly used in hospital laboratories.

Events Organized by NDTL

Since its inception, NDTL has organized many events as follows:[9]

See also

External links

Notes and References

  1. Web site: Management & Staff Ndtl. ndtlindia.com. 2016-11-24.
  2. Web site: Introduction Ndtl. ndtlindia.com. 2016-11-23.
  3. Web site: Accreditation of NDTL Ndtl. ndtlindia.com. 2016-11-23.
  4. Web site: Copenhagen Declaration List of Signatories. World Anti-Doping Agency. 2016-11-24.
  5. Web site: Copenhagen Declaration. 2016-11-24.
  6. Web site: Research Projects Ndtl. ndtlindia.com. 2016-11-23.
  7. S. b) Jain. R. Lal. A. Raj. D. Tyagi. A. Beotra. T. Kaur. 2012-01-01. Characteristics of IEF Patterns and SDS-PAGE of Indian EPO Biosimilars. ResearchGate. 10.13140/2.1.1917.0243.
  8. Web site: Instrument & Technologies. 2016-11-23.
  9. Web site: International Conference 2016 - Previous events organised by NDTL. ndtlconference2016.zohosites.com. 2016-11-23.
  10. Web site: International Conference 2016 - Programme Schedule. ndtlconference2016.zohosites.com. 2016-11-23.

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