| Natalya Deryugina | |
| Birth Date: | 23 April 1971 |
| Birth Place: | Moscow |
| Clubs1: | Luch Moscow |
| Years1: | 1994 |
| Clubs2: | Viborg HK |
| Years2: | 1994–2003 |
| Clubs3: | Aalborg DH |
| Years3: | 2003–2008 |
Natalya Deryugina (Russian: Наталья Дерюгина, born April 23, 1971) is a former Russian handball player on the Unified Team at the 1992 Summer Olympics which won the bronze medals. She played every match and scored 14 goals.